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Cites:

1

Information Journal Paper

Title

INVESTIGATION OF CYTOTOXIC ACTIVITY IN FOUR STACHYS SPECIES FROM IRAN

Pages

  589-593

Abstract

 The aerial parts of STACHYS LAXA BOISS. AND BUHSE. from Siah-bishe in Mazandaran province, STACHYS TRINERVIS AITCH. AND HEMSL. from Karaj in Alborz province, STACHYS SUBAPHYLLA RECH. F. and STACHYS TURCOMANICA TRAUTV. from Golestan province have been collected in May 2008. Total extracts were obtained through MeOH/H2O (80/20) and then partitioned between CHCl3, EtOAc and MeOH. These fractions and total extracts have been investigated for in-vitro CYTOTOXIC ACTIVITY against the colon carcinoma (HT-29), colorectal adenocarcinoma (Caco-2), breast ductal carcinoma (T47D) and Swiss mouse embryo fibroblast (NIH 3T3) cell lines using MTT ASSAY (3- (4, 5-di methyl thiazol-2-yl) -2, 5-di phenyltetrazolium bromide). At each cell line, doses of 3.125, 6.25, 12.5, 25, 100, 200, 400 and 800 mg/mL in 1% (v/v) DMSO of all samples were tested. Ethyl acetate and chloroform fractions of Stachys laxa against proliferation of T47D and HT-29 cell lines and chloroform fraction of Stachys subaphylla and Stachys subaphylla ethyl acetate fraction toward T47D cell line exhibited highest CYTOTOXIC ACTIVITY (IC50<50 mg/mL). Ethyl acetate and chloroform fractions of Stachys turcomanica against HT-29 cell line, except methanol fraction of Stachys subaphylla, the other extrcts on T47D cell line, represented moderate CYTOTOXIC ACTIVITY (IC50<70 mg/mL). All fractions of S. trinervis demonstrated no effective CYTOTOXIC ACTIVITY. IC50 values confirmed that the growth and proliferation of HT-29 and T47D cells were most affected by chloroform and ethyl acetate fractions of Stachys laxa and Stachys turcomanica due to their nonpolar compounds.

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    • Cite

    APA: Copy

    KHANAVI, MAHNAZ, MANAYI, AZADEH, LOTFI, MAHNAZ, ABBASI, ROFEYDE, MAJDZADEH, MARYAM, & OSTAD, SEYED NASSER. (2012). INVESTIGATION OF CYTOTOXIC ACTIVITY IN FOUR STACHYS SPECIES FROM IRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 589-593. SID. https://sid.ir/paper/287949/en

    Vancouver: Copy

    KHANAVI MAHNAZ, MANAYI AZADEH, LOTFI MAHNAZ, ABBASI ROFEYDE, MAJDZADEH MARYAM, OSTAD SEYED NASSER. INVESTIGATION OF CYTOTOXIC ACTIVITY IN FOUR STACHYS SPECIES FROM IRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):589-593. Available from: https://sid.ir/paper/287949/en

    IEEE: Copy

    MAHNAZ KHANAVI, AZADEH MANAYI, MAHNAZ LOTFI, ROFEYDE ABBASI, MARYAM MAJDZADEH, and SEYED NASSER OSTAD, “INVESTIGATION OF CYTOTOXIC ACTIVITY IN FOUR STACHYS SPECIES FROM IRAN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 589–593, 2012, [Online]. Available: https://sid.ir/paper/287949/en

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