ARTICLE UMBELLIPRENIN INDUCES APOPTOSIS IN CLL CELL LINES

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ZIAI SEYED ALI; GHOLAMI OMID; IRANSHAHI MEHRDAD; ZAMANI AMIR HASSAN; JEDDI TEHRANI MAHMOOD

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:2 Page(s): 653-659

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Title

ARTICLE UMBELLIPRENIN INDUCES APOPTOSIS IN CLL CELL LINES

Author(s)

Keywords

CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)

UMBELLIPRENIN

APOPTOSIS

INTERLEUKIN 4 (IL-4)

FLOWCYTOMETRY

Abstract

Chronic lymphocytic leukemia (CLL) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. Many Ferula species, including F. asa-foetida, synthesize terpenyloxy coumarins. One of these coumarins is UMBELLIPRENIN, which has been implicated with induction of APOPTOSIS in some cancer cell lines.In this study induction of APOPTOSIS by UMBELLIPRENIN on Jurkat T-CLL and Raji B-CLL cell lines was studied. In this regard, cells were incubated with various concentrations of UMBELLIPRENINin-vitro for different times and assayed for APOPTOSIS with annexin V–FITC/PI double staining FLOWCYTOMETRY method. Results showed that UMBELLIPRENIN induced APOPTOSIS in leukemic cells in a dose- and time-dependent manner and that CLL cells were more susceptible to UMBELLIPRENIN induced cell death than normal peripheral blood mononuclear cell (PBMCs).Moreover, we study the induction of APOPTOSIS in Jurkat cells by UMBELLIPRENIN in the presence of interleukin 4 (IL-4) as an agent that causes resistance to APOPTOSIS in CLL cells, was also student. We showed that IL-4 can not reduce apoptotic effect of UMBELLIPRENIN.The preferential toxicity of UMBELLIPRENIN for CLL cells, supports the hypothesis that oral administration of UMBELLIPRENIN in the form of foods or folk medicines containing this coumarin, might enhance protection against the development of CLL in man with little side effects. In conclusion, UMBELLIPRENIN may be an effective therapeutic agent in the treatment of CLL, and thus clinical studies with UMBELLIPRENIN may be appropriate.

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APA: Copy

ZIAI, SEYED ALI, GHOLAMI, OMID, IRANSHAHI, MEHRDAD, ZAMANI, AMIR HASSAN, & JEDDI TEHRANI, MAHMOOD. (2012). ARTICLE UMBELLIPRENIN INDUCES APOPTOSIS IN CLL CELL LINES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 653-659. SID. https://sid.ir/paper/287953/en

Vancouver: Copy

ZIAI SEYED ALI, GHOLAMI OMID, IRANSHAHI MEHRDAD, ZAMANI AMIR HASSAN, JEDDI TEHRANI MAHMOOD. ARTICLE UMBELLIPRENIN INDUCES APOPTOSIS IN CLL CELL LINES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):653-659. Available from: https://sid.ir/paper/287953/en

IEEE: Copy

SEYED ALI ZIAI, OMID GHOLAMI, MEHRDAD IRANSHAHI, AMIR HASSAN ZAMANI, and MAHMOOD JEDDI TEHRANI, “ARTICLE UMBELLIPRENIN INDUCES APOPTOSIS IN CLL CELL LINES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 653–659, 2012, [Online]. Available: https://sid.ir/paper/287953/en

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