FORMULATION AND IN-VITRO EVALUATION OF PH-SENSITIVE OIL ENTRAPPED POLYMERIC BLEND AMOXICILLIN BEADS FOR THE ERADICATION OF HELICOBACTER PYLORI

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TRIPATHI GIRISH KUMAR; SINGH SATYAWAN; NATH GOPAL

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:2 Page(s): 447-455

Download Full-Text

View:

506

Download:

159

Cites:

Information Journal Paper

Title

FORMULATION AND IN-VITRO EVALUATION OF PH-SENSITIVE OIL ENTRAPPED POLYMERIC BLEND AMOXICILLIN BEADS FOR THE ERADICATION OF HELICOBACTER PYLORI

Author(s)

TRIPATHI GIRISH KUMAR | SINGH SATYAWAN | NATH GOPAL | Issue Writer Certificate

Keywords

AMOXICILLIN

PH SENSITIVE DRUG DELIVERY SYSTEM

MINIMUM INHIBITORY CONCENTRATION (MIC)

GASTRIC RETENTION

Abstract

Oral PH SENSITIVE DRUG DELIVERY SYSTEMs are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (GI) as per the pH of GI, resulting in improved patient therapeutic efficacy and compliance. The pH range of fluids in various segments of the GI tract may provide environmental stimuli for drug release. The aim of this study was to design buoyant beads containing AMOXICILLIN (Am) and to evaluate its potential for the eradication of Helicobacter pylori (H. pylori). The gel bead of gellan, wherein the oil was entrapped, was blended with hydroxypropyl methyl cellulose or Carbopol 934. Buoyant beads of gellan were prepared through ionotropic gellation technique to achieve the controlled and pH-sensitive drug release in stomach. The effects of processing variables such as particle size, buoyancy, percent encapsulation efficiency and in-vitro antimicrobial activity were evaluated. The scanning electron micrograph indicated that prepared beads were spherical in shape and all the beads showed satisfactory floating efficiency in the phthalate buffer solution. The diameter of the gel beads was increased through raising the gellan gum and calcium carbonate concentration. The formulation exhibited sustained release profile and was best fitted in the Peppas model with n<0.45. Subsequent coating of microbeads exhibited zero-order sustained pattern of the drug release up to 8 h. In-vitro growth inhibition study showed complete eradication of the isolated H. pylori strain. These results provide evidence that the optimized formulation bearing antibiotics like AMOXICILLIN should be useful in H. pylori treatment.

Cites

GREEN SYNTHESIS AND UREASE INHIBITORY ACTIVITY OF SPIRO-PYRIMIDINETHIONES/SPIRO-PYRIMIDINONES-BARBITURIC ACID DERIVATIVES

References

No record.

Cite

APA: Copy

TRIPATHI, GIRISH KUMAR, SINGH, SATYAWAN, & NATH, GOPAL. (2012). FORMULATION AND IN-VITRO EVALUATION OF PH-SENSITIVE OIL ENTRAPPED POLYMERIC BLEND AMOXICILLIN BEADS FOR THE ERADICATION OF HELICOBACTER PYLORI. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 447-455. SID. https://sid.ir/paper/287960/en

Vancouver: Copy

TRIPATHI GIRISH KUMAR, SINGH SATYAWAN, NATH GOPAL. FORMULATION AND IN-VITRO EVALUATION OF PH-SENSITIVE OIL ENTRAPPED POLYMERIC BLEND AMOXICILLIN BEADS FOR THE ERADICATION OF HELICOBACTER PYLORI. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):447-455. Available from: https://sid.ir/paper/287960/en

IEEE: Copy

GIRISH KUMAR TRIPATHI, SATYAWAN SINGH, and GOPAL NATH, “FORMULATION AND IN-VITRO EVALUATION OF PH-SENSITIVE OIL ENTRAPPED POLYMERIC BLEND AMOXICILLIN BEADS FOR THE ERADICATION OF HELICOBACTER PYLORI,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 447–455, 2012, [Online]. Available: https://sid.ir/paper/287960/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops