مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

A COMPREHENSIVE REVIEW OF PUNICA GRANATUM (POMEGRANATE) PROPERTIES IN TOXICOLOGICAL, PHARMACOLOGICAL, CELLULAR AND MOLECULAR BIOLOGY RESEARCHES

Pages

  385-400

Abstract

 PUNICA GRANATUM (Pg), commonly known as pomegranate (Pg), is a member of the monogeneric family, Punicaceae, and is mainly found in Iran which is considered to be its primary centre of origin. Pg and its CHEMICAL COMPONENTS possess various pharmacological and TOXICOLOGICAL PROPERTIES including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiogenesis activities. They also show inhibitory effects on invasion/motility, cell cycle, apoptosis, and vital enzymes such as cyclooxygenase (COX), lipooxygenase (LOX), cytochrome P450 (CYP450), phospholipase A2 (PLA2), ornithine decarboxylase (ODC), carbonic anhydrase (CA), 17beta-hydroxysteroid dehydrogenase (17b-HSDs) and serine protease (SP). Furthermore, they can stimulate cell differentiation and possess anti-mutagenic effects. Pg can also interfere with several SIGNALING PATHWAYs including PI3K/AKT, mTOR, PI3K, Bcl-X, Bax, Bad, MAPK, ERK1/2, P38, JNK, and caspase. However, the exact mechanisms for its pharmacological and TOXICOLOGICAL PROPERTIES remain to be unclear and need further evaluation. These properties strongly suggest a wide range use of Pg for CLINICAL APPLICATIONS. This review will discuss the areas for which Pg has shown therapeutic properties in different mechanisms.

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    • Cite

    APA: Copy

    RAHIMI, HAMID REZA, ARASTOO, MOHAMMAD, & OSTAD, SEYED NASSER. (2012). A COMPREHENSIVE REVIEW OF PUNICA GRANATUM (POMEGRANATE) PROPERTIES IN TOXICOLOGICAL, PHARMACOLOGICAL, CELLULAR AND MOLECULAR BIOLOGY RESEARCHES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 385-400. SID. https://sid.ir/paper/287973/en

    Vancouver: Copy

    RAHIMI HAMID REZA, ARASTOO MOHAMMAD, OSTAD SEYED NASSER. A COMPREHENSIVE REVIEW OF PUNICA GRANATUM (POMEGRANATE) PROPERTIES IN TOXICOLOGICAL, PHARMACOLOGICAL, CELLULAR AND MOLECULAR BIOLOGY RESEARCHES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):385-400. Available from: https://sid.ir/paper/287973/en

    IEEE: Copy

    HAMID REZA RAHIMI, MOHAMMAD ARASTOO, and SEYED NASSER OSTAD, “A COMPREHENSIVE REVIEW OF PUNICA GRANATUM (POMEGRANATE) PROPERTIES IN TOXICOLOGICAL, PHARMACOLOGICAL, CELLULAR AND MOLECULAR BIOLOGY RESEARCHES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 385–400, 2012, [Online]. Available: https://sid.ir/paper/287973/en

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