RELIABILITY OF DISK DIFFUSION TEST RESULTS FOR THE ANTIMICROBIAL SUSCEPTIBILITY TESTING OF NOSOCOMIAL GRAM-POSITIVE MICROORGANISMS: IS E-TEST METHOD BETTER?

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KHALILI HOSSEIN; SOLTANI RASOOL; NEGAHBAN SORROSH; ABDOLLAHI ALIREZA; GHOLAMI KEIROLLAH

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:2 Page(s): 559-563

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Title

RELIABILITY OF DISK DIFFUSION TEST RESULTS FOR THE ANTIMICROBIAL SUSCEPTIBILITY TESTING OF NOSOCOMIAL GRAM-POSITIVE MICROORGANISMS: IS E-TEST METHOD BETTER?

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Keywords

GRAM-POSITIVE

ANTIMICROBIAL SUSCEPTIBILITY TEST

DISK DIFFUSION

E-TEST

Abstract

Disk diffusion test is the usual applicable method for assessing the antimicrobial susceptibility pattern in most institutions and hospitals. The aim of this study was to determine the reliability of resistant-reported results of DISK DIFFUSION test for 6 routinely used antibiotics against GRAM-POSITIVE microorganisms of nosocomial origin, using E-TEST method.Over a 1-year period, clinical specimens (e.g. blood, tracheal secretions, wound secretions, urine, etc.) were obtained from hospitalized patients with defined nosocomial infection and were cultured. Isolated GRAM-POSITIVE bacteria underwent DISK DIFFUSION test for cephalothin, oxacillin, clindamycin, ciprofloxacin, vancomycin, teicoplanin (only for Enterococci), and meropenem antibiotics. E-TEST method was performed for all isolates resistant or intermediately sensitive to the disks of any mentioned antibiotics.Data showed compatible results of DISK DIFFUSION test with the results of E-TEST method for cephalothin, oxacillin, ciprofloxacin, vancomycin, and teicoplanin. None of ciprofloxacin- and vancomycin-resistant isolates in DISK DIFFUSION test showed sensitivity in E-TEST method. Significant differences between the results of DISK DIFFUSION and E-TEST methods were observed for clindamycin and meropenem against S.aureus (p=0.01 and 0.04, respectively) and Enterococcus spp (p=0.03 and 0.02, respectively).In order to increase the reliability of antimicrobial susceptibility results, it is recommended to perform E-TEST for nosocomial GRAM-POSITIVE microorganisms that show antibiotic resistance by DISK DIFFUSION test and it is more important for clindamycin and meropenem.

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APA: Copy

KHALILI, HOSSEIN, SOLTANI, RASOOL, NEGAHBAN, SORROSH, ABDOLLAHI, ALIREZA, & GHOLAMI, KEIROLLAH. (2012). RELIABILITY OF DISK DIFFUSION TEST RESULTS FOR THE ANTIMICROBIAL SUSCEPTIBILITY TESTING OF NOSOCOMIAL GRAM-POSITIVE MICROORGANISMS: IS E-TEST METHOD BETTER?. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 559-563. SID. https://sid.ir/paper/287975/en

Vancouver: Copy

KHALILI HOSSEIN, SOLTANI RASOOL, NEGAHBAN SORROSH, ABDOLLAHI ALIREZA, GHOLAMI KEIROLLAH. RELIABILITY OF DISK DIFFUSION TEST RESULTS FOR THE ANTIMICROBIAL SUSCEPTIBILITY TESTING OF NOSOCOMIAL GRAM-POSITIVE MICROORGANISMS: IS E-TEST METHOD BETTER?. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):559-563. Available from: https://sid.ir/paper/287975/en

IEEE: Copy

HOSSEIN KHALILI, RASOOL SOLTANI, SORROSH NEGAHBAN, ALIREZA ABDOLLAHI, and KEIROLLAH GHOLAMI, “RELIABILITY OF DISK DIFFUSION TEST RESULTS FOR THE ANTIMICROBIAL SUSCEPTIBILITY TESTING OF NOSOCOMIAL GRAM-POSITIVE MICROORGANISMS: IS E-TEST METHOD BETTER?,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 559–563, 2012, [Online]. Available: https://sid.ir/paper/287975/en

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