ANTINOCICEPTIVE AND SMOOTH MUSCLE RELAXANT ACTIVITY OF CROTON TIGLIUM L SEED: AN IN-VITRO AND IN-VIVO STUDY

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LIU ZHEN; GAO WENYUAN; ZHANG JINGZE; HU JING

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:2 Page(s): 611-620

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Information Journal Paper

Title

ANTINOCICEPTIVE AND SMOOTH MUSCLE RELAXANT ACTIVITY OF CROTON TIGLIUM L SEED: AN IN-VITRO AND IN-VIVO STUDY

Author(s)

LIU ZHEN | GAO WENYUAN | ZHANG JINGZE | HU JING | Issue Writer Certificate

Keywords

CROTON TIGLIUM L

INTESTINAL PROPULSION

SMOOTH MUSCLE

RABBIT JEJUNUM

ANTINOCICEPTIVE

PHORBOL ESTERS

Abstract

The seed of CROTON TIGLIUM L. (SCT) is a well known folk medicine. In China, it has used to treat gastrointestinal disorders, intestinal inflammation, rheumatism, and so on. Previous studies established its purgative and inflammation properties. In addition, the effects of essential oil of SCT on intestinal transit and gastrointestinal tract has been studied. In the present study, we evaluated the ANTINOCICEPTIVE effect of SCT through the writhing test in mice, investigated the effects of it on spontaneous SMOOTH MUSCLE contractions of isolated RABBIT JEJUNUM and examined the in-vitro results through the in-vivo small intestine propulsion. We further investigated the possible compounds using HPLC-MS, and six compounds were tentatively identified as PHORBOL ESTERS. Furthermore, the possible fragmentation pathways of PHORBOL ESTERS were proposed, and we also detected the possible compounds in the active parts.

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APA: Copy

LIU, ZHEN, GAO, WENYUAN, ZHANG, JINGZE, & HU, JING. (2012). ANTINOCICEPTIVE AND SMOOTH MUSCLE RELAXANT ACTIVITY OF CROTON TIGLIUM L SEED: AN IN-VITRO AND IN-VIVO STUDY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 611-620. SID. https://sid.ir/paper/287977/en

Vancouver: Copy

LIU ZHEN, GAO WENYUAN, ZHANG JINGZE, HU JING. ANTINOCICEPTIVE AND SMOOTH MUSCLE RELAXANT ACTIVITY OF CROTON TIGLIUM L SEED: AN IN-VITRO AND IN-VIVO STUDY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):611-620. Available from: https://sid.ir/paper/287977/en

IEEE: Copy

ZHEN LIU, WENYUAN GAO, JINGZE ZHANG, and JING HU, “ANTINOCICEPTIVE AND SMOOTH MUSCLE RELAXANT ACTIVITY OF CROTON TIGLIUM L SEED: AN IN-VITRO AND IN-VIVO STUDY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 611–620, 2012, [Online]. Available: https://sid.ir/paper/287977/en

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