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Information Journal Paper

Title

THE LIPOPHILICITY EXAMINATION OF SOME ACE INHIBITORS AND HYDROCHLOROTHIAZIDE ON CELLULOSE IN RP THIN-LAYER CHROMATOGRAPHY

Pages

  763-770

Abstract

 In this assay, the evaluation of LIPOPHILICITY of four ACE-inhibitors and HYDROCHLOROTHIAZIDE (HCTZ) with RP-TLC on cellulose layers was described using three binary solvent systems. The selected ACE INHIBITORS had sufficiently different structures which can indicate the method suitability for their LIPOPHILICITY evaluation as the model substances in comparison with HCTZ.In addition, the linear relationship between the RM-values and composition of mobile phases was established in the current study. From the regression data of the plots, the hydrophobicity parameters, R 0M and m, were determined and C0 parameter was calculated. The correlations between the experimentally obtained hydrophobicity parameters and calculated log p values were studied. Furthermore, the obtained results were compared with those previously obtained on RP-18 modified silica gel. Very good correlation (r=0.91; water-ethanol solvent system) between the chromatographically obtained hydrophobicity parameters and calculated log p values confirmed the selection of ACE INHIBITORS since lisinopril and quinapril were on the opposite sites of linear relationship. The results indicate that cellulose as an easily available sorbent can be successfully used for the LIPOPHILICITY investigation of examined substances with RP-TLC.

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    APA: Copy

    ODOVIC, JADRANKA, KARLJIKOVIC RAJIC, KATARINA, TRBOJEVIC STANKOVIC, JASNA, STOJIMIROVIC, BILJANA, & VLADIMIROV, SOTE. (2012). THE LIPOPHILICITY EXAMINATION OF SOME ACE INHIBITORS AND HYDROCHLOROTHIAZIDE ON CELLULOSE IN RP THIN-LAYER CHROMATOGRAPHY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 763-770. SID. https://sid.ir/paper/287979/en

    Vancouver: Copy

    ODOVIC JADRANKA, KARLJIKOVIC RAJIC KATARINA, TRBOJEVIC STANKOVIC JASNA, STOJIMIROVIC BILJANA, VLADIMIROV SOTE. THE LIPOPHILICITY EXAMINATION OF SOME ACE INHIBITORS AND HYDROCHLOROTHIAZIDE ON CELLULOSE IN RP THIN-LAYER CHROMATOGRAPHY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):763-770. Available from: https://sid.ir/paper/287979/en

    IEEE: Copy

    JADRANKA ODOVIC, KATARINA KARLJIKOVIC RAJIC, JASNA TRBOJEVIC STANKOVIC, BILJANA STOJIMIROVIC, and SOTE VLADIMIROV, “THE LIPOPHILICITY EXAMINATION OF SOME ACE INHIBITORS AND HYDROCHLOROTHIAZIDE ON CELLULOSE IN RP THIN-LAYER CHROMATOGRAPHY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 763–770, 2012, [Online]. Available: https://sid.ir/paper/287979/en

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