EFFECTS OF THREE MEDICINAL PLANTS EXTRACTS IN EXPERIMENTAL DIABETES: ANTIOXIDANT ENZYMES ACTIVITIES AND PLASMA LIPIDS PROFILES INCOMPARISON WITH METFORMIN

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FEHRESTI SANI MOHAMMAD; MONTASSER KOUHSARI SHIDEH; MORADABADI LEILA

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:3 Page(s): 897-903

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Title

EFFECTS OF THREE MEDICINAL PLANTS EXTRACTS IN EXPERIMENTAL DIABETES: ANTIOXIDANT ENZYMES ACTIVITIES AND PLASMA LIPIDS PROFILES INCOMPARISON WITH METFORMIN

Author(s)

FEHRESTI SANI MOHAMMAD | MONTASSER KOUHSARI SHIDEH | MORADABADI LEILA | Issue Writer Certificate

Keywords

ALLIUM ASCALONICUM

ALLIUM SATIVUM

SALVIA OF FI CINALIS

ANTIOXIDANT ENZYMES

PLASMA LIPIDS

Abstract

In the present study we aimed to evaluate the effects of methanolic extracts of the bulbs of Garlic (Allium sativum L., Alliaceae) and Persian shallot (ALLIUM ASCALONICUM L., Alliaceae) and leaves of Sage (Salvia officinalis L., Lamiaceae), ASE, AAE and SOE respectively, on the ANTIOXIDANT ENZYMES such as superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) activities and on the levels of PLASMA LIPIDS profiles such as triglycerides (TG), total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL) in Alloxan diabetic Wistar rats.In comparison with diabetic control rats in diabetic treated rats, AAE increases the activities of SOD (65%), GPX (43%) and CAT (55%). ASE and SOE increase SOD activity by 60% and 33% respectively. ASE reduces TC (34%), SOE decreases TG (40%) and LDL (30%) and AAE reduces VLDL (24%). Metformin exhibits mild antioxidant and hypolipidemic properties. Results of quantitative phytochemical analysis show that the methanolic garlic and Persian shallot bulbs extracts contain secondary metabolites including alkaloids (3.490% and 3.430%), glycosides (18.023% and 13.301%) and saponins (0.812% and 0.752%). Methanolic sageleaves extract contains flavonoids (1.014%), glycosides (23.142%) and saponins (2.096%). The total phenolic contents of ASE, AAE and SOE were in order 4.273, 3.621 and 6.548 mg GAE/g dry weight (DW).These results suggest thatAllium sativum, ALLIUM ASCALONICUM and Salvia officinalis are beneficial in the control of diabetes by noticeable antioxidant and hypolipidemic properties.

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APA: Copy

FEHRESTI SANI, MOHAMMAD, MONTASSER KOUHSARI, SHIDEH, & MORADABADI, LEILA. (2012). EFFECTS OF THREE MEDICINAL PLANTS EXTRACTS IN EXPERIMENTAL DIABETES: ANTIOXIDANT ENZYMES ACTIVITIES AND PLASMA LIPIDS PROFILES INCOMPARISON WITH METFORMIN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 897-903. SID. https://sid.ir/paper/287986/en

Vancouver: Copy

FEHRESTI SANI MOHAMMAD, MONTASSER KOUHSARI SHIDEH, MORADABADI LEILA. EFFECTS OF THREE MEDICINAL PLANTS EXTRACTS IN EXPERIMENTAL DIABETES: ANTIOXIDANT ENZYMES ACTIVITIES AND PLASMA LIPIDS PROFILES INCOMPARISON WITH METFORMIN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):897-903. Available from: https://sid.ir/paper/287986/en

IEEE: Copy

MOHAMMAD FEHRESTI SANI, SHIDEH MONTASSER KOUHSARI, and LEILA MORADABADI, “EFFECTS OF THREE MEDICINAL PLANTS EXTRACTS IN EXPERIMENTAL DIABETES: ANTIOXIDANT ENZYMES ACTIVITIES AND PLASMA LIPIDS PROFILES INCOMPARISON WITH METFORMIN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 897–903, 2012, [Online]. Available: https://sid.ir/paper/287986/en

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