MUCOSAL ADJUVANT POTENTIAL OF QUILLAJA SAPONINS AND CROSS-LINKED DEXTRAN MICROSPHERES, CO-ADMINISTERED WITH LIPOSOMES ENCAPSULATED WITH TETANUS TOXOI

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MOGHADAM ARIAEE FAEZEH; TAFAGHODI MOHSEN

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:3 Page(s): 723-732

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Title

MUCOSAL ADJUVANT POTENTIAL OF QUILLAJA SAPONINS AND CROSS-LINKED DEXTRAN MICROSPHERES, CO-ADMINISTERED WITH LIPOSOMES ENCAPSULATED WITH TETANUS TOXOI

Author(s)

MOGHADAM ARIAEE FAEZEH | TAFAGHODI MOHSEN | Issue Writer Certificate

Keywords

NASAL IMMUNIZATION

TETANUS TOXOID

QUILLAJA SAPONIN

LIPOSOMES

CROSS-LINKED

DEXTRAN MICROSPHERES

Abstract

Intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. However, soluble antigens (Ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. So, in this study, TETANUS TOXOID (TT) as a model Ag was entrapped in nonionic LIPOSOMES. The effect of the co-administration of QUILLAJA SAPONIN (QS) as an adjuvant and CROSS-LINKED DEXTRAN MICROSPHERES (CDM) as penetration enhancer on immune responses was also studied. TT or TT+QS loaded LIPOSOMES were prepared by dehydration-rehydration method (DRV), followed by the extrusion through 400 nm filters. Some formulations were mixed with CDM. LIPOSOMES were first characterized for their size range, mean diameter and morphology using particle size analyzer, optical and transmission electron microscopes. The volume mean diameter of LIPOSOMES was determined as 3836±179 and 624±114 nm before and after the extrusion, respectively. Structural efficiency of TT extracted from LIPOSOMES was confirmed by SDS-PAGE method. Encapsulation efficiencies of TT and QS were 44±8.50% and 60±6.02%, respectively. Rabbits were nasally immunized with various formulations and serum IgG titers and nasal lavage sIgA titers were determined by an ELISA method. TT+QS LIPOSOMES induced higher sIgA levels in comparison with TT LIPOSOMES (p<0.05), but the difference in serum IgG levels was not significant. Results indicated that neutral LIPOSOMES administered nasally, have a good potential for induction of mucosal immunity and co-encapsulation of QS and TT in LIPOSOMES improved the systemic and mucosal immune responses.

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APA: Copy

MOGHADAM ARIAEE, FAEZEH, & TAFAGHODI, MOHSEN. (2012). MUCOSAL ADJUVANT POTENTIAL OF QUILLAJA SAPONINS AND CROSS-LINKED DEXTRAN MICROSPHERES, CO-ADMINISTERED WITH LIPOSOMES ENCAPSULATED WITH TETANUS TOXOI. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 723-732. SID. https://sid.ir/paper/287999/en

Vancouver: Copy

MOGHADAM ARIAEE FAEZEH, TAFAGHODI MOHSEN. MUCOSAL ADJUVANT POTENTIAL OF QUILLAJA SAPONINS AND CROSS-LINKED DEXTRAN MICROSPHERES, CO-ADMINISTERED WITH LIPOSOMES ENCAPSULATED WITH TETANUS TOXOI. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):723-732. Available from: https://sid.ir/paper/287999/en

IEEE: Copy

FAEZEH MOGHADAM ARIAEE, and MOHSEN TAFAGHODI, “MUCOSAL ADJUVANT POTENTIAL OF QUILLAJA SAPONINS AND CROSS-LINKED DEXTRAN MICROSPHERES, CO-ADMINISTERED WITH LIPOSOMES ENCAPSULATED WITH TETANUS TOXOI,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 723–732, 2012, [Online]. Available: https://sid.ir/paper/287999/en

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