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Information Journal Paper

Title

CHRONIC ORAL EPIGALLOCATECHIN-GALLATE ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS

Pages

  1243-1253

Abstract

 Due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate(EGCG), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of EGCG on alleviation of HYPERALGESIA in streptozotocin-diabetic (STZ-diabetic) rats. Male Wistar rats were divided into control, diabetic, EGCG-treated-control and diabetic and sodium salicylate (SS) -treated control and diabetic groups. For induction of diabetes, STZ was intraperitoneally injected (IP) at a single dose of 60 mg/Kg. EGCG was orally administered daily at doses of 20 and 40 mg/Kg for seven weeks, one week after diabetes induction. Finally, HYPERALGESIA was assessed using standard formalin, hot tail immersion and paw pressure tests. Meanwhile, markers of OXIDATIVE STRESS in brain were measured. DIABETIC RATs showed a marked chemical, thermal and paw pressure HYPERALGESIA, indicating that the development of diabetic neuropathy and EGCG treatment at a dose 40 mg/Kg significantly ameliorated the alteration in HYPERALGESIA (p<0.05) in DIABETIC RATs as compared with untreated diabetics. EGCG treatment (40 mg/Kg) also significantly decreased diabetes-induced thiobarbituric acid reactive substances formation (p<0.05) and nitrite (p<0.05) content and reversed the reduction of antioxidant defensive enzyme superoxide dismutase (p<0.05). The results may suggest therapeutic potential of EGCG for the treatment of diabetic HYPERALGESIA through the attenuation of OXIDATIVE STRESS.

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    APA: Copy

    BALUCHNEJADMOJARAD, TOURANDOKHT, & ROGHANI, MEHRDAD. (2012). CHRONIC ORAL EPIGALLOCATECHIN-GALLATE ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(4), 1243-1253. SID. https://sid.ir/paper/288014/en

    Vancouver: Copy

    BALUCHNEJADMOJARAD TOURANDOKHT, ROGHANI MEHRDAD. CHRONIC ORAL EPIGALLOCATECHIN-GALLATE ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(4):1243-1253. Available from: https://sid.ir/paper/288014/en

    IEEE: Copy

    TOURANDOKHT BALUCHNEJADMOJARAD, and MEHRDAD ROGHANI, “CHRONIC ORAL EPIGALLOCATECHIN-GALLATE ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 4, pp. 1243–1253, 2012, [Online]. Available: https://sid.ir/paper/288014/en

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