HEPATOPROTECTIVE EFFECT OF OTOSTEGIA PERSICA BOISS. SHOOT EXTRACT ON CARBON TETRACHLORIDE-INDUCED ACUTE LIVER DAMAGE IN RATS

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NASIRI BEZENJANI SEDIGHE; POURABOLI IRAN; MALEKPOUR AFSHAR REZA; MOHAMMADI GHOLAM ABAS

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:4 Page(s): 1219-1226

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Title

HEPATOPROTECTIVE EFFECT OF OTOSTEGIA PERSICA BOISS. SHOOT EXTRACT ON CARBON TETRACHLORIDE-INDUCED ACUTE LIVER DAMAGE IN RATS

Author(s)

NASIRI BEZENJANI SEDIGHE | POURABOLI IRAN | MALEKPOUR AFSHAR REZA | MOHAMMADI GHOLAM ABAS | Issue Writer Certificate

Keywords

OTOSTEGIA PERSICA

HEPATOPROTECTIVE

CARBON TETRACHLORIDE

HISTOPATHOLOGY

MDA

GSH

Abstract

Hepatoprotective Effect of OTOSTEGIA PERSICA Boiss. Shoot Extract on CARBON TETRACHLORIDE-Induced Acute Liver Damage in Rats In this study, the HEPATOPROTECTIVE effect of the methanol extract of aerial parts (shoot) fromOTOSTEGIA PERSICA Boiss (Golder) was investigated against the CARBON TETRACHLORIDE (CCl4) -induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl4 in liquid paraffin (2.5 mL/Kg bw, per os) 60 min after the administration of the methanol extract of O. persica shoot (in 200, 300, 400 mg/Kg bw doses) and assessed using biochemical parameters (plasma and liver tissue malondialdehyde (MDA), transaminase enzyme levels in plasma [aspartate transaminase (AST), alanine aminotransferase (ALT)] and liver glutathione (GSH) levels). Results show that the methanol extract of O. persica shoot is active at 300 mg/Kg (per os) and it possess remarkable antioxidant and HEPATOPROTECTIVE activities. Additionally, histopathological studies verified the effectiveness of this dose of extract in acute liver damage prevention.

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APA: Copy

NASIRI BEZENJANI, SEDIGHE, POURABOLI, IRAN, MALEKPOUR AFSHAR, REZA, & MOHAMMADI, GHOLAM ABAS. (2012). HEPATOPROTECTIVE EFFECT OF OTOSTEGIA PERSICA BOISS. SHOOT EXTRACT ON CARBON TETRACHLORIDE-INDUCED ACUTE LIVER DAMAGE IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(4), 1219-1226. SID. https://sid.ir/paper/288015/en

Vancouver: Copy

NASIRI BEZENJANI SEDIGHE, POURABOLI IRAN, MALEKPOUR AFSHAR REZA, MOHAMMADI GHOLAM ABAS. HEPATOPROTECTIVE EFFECT OF OTOSTEGIA PERSICA BOISS. SHOOT EXTRACT ON CARBON TETRACHLORIDE-INDUCED ACUTE LIVER DAMAGE IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(4):1219-1226. Available from: https://sid.ir/paper/288015/en

IEEE: Copy

SEDIGHE NASIRI BEZENJANI, IRAN POURABOLI, REZA MALEKPOUR AFSHAR, and GHOLAM ABAS MOHAMMADI, “HEPATOPROTECTIVE EFFECT OF OTOSTEGIA PERSICA BOISS. SHOOT EXTRACT ON CARBON TETRACHLORIDE-INDUCED ACUTE LIVER DAMAGE IN RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 4, pp. 1219–1226, 2012, [Online]. Available: https://sid.ir/paper/288015/en

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