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Information Journal Paper

Title

SYNTHESIS AND ANTI-INFLAMMATORY PERFORMANCE OF NEWLY CYCLIZINE DERIVATIVES ON ADULT MALE WISTAR RATS

Pages

  1027-1037

Abstract

 CYCLIZINE (1-benzhydryl-4-methyl-piperazine, CAS 82-92-8, CYC, I), a PIPERAZINE DERIVATIVE, belongs to H1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other H1-receptor antagonists. In this study, two new tolyl and cumene derivatives of I (1-ethyl- 4- [(p-isopropylphenyl) (p -tolyl) methyl] -piperazine, II and 1- [3, 4-dichlorophenyl] -4- [[p-isopropylphenyl] [p-tolyl] methyl] -piperazine, III) were synthesized to investigate their ACUTE AND CHRONIC anti-inflammatory activities in formalin and histamine-induced rat paw edema. In addition, the vascular permeability in formalin and histamine-induced paw edema, xylene-induced ear edema, and peritonitis due to acetic acid application into peritoneal cavity were measured. The cotton pellet-induced granuloma model was chosen for inducing chronic inflammation in rats. Findings proved reduction in formalin-induced rat paw edema and vascular permeability (acute inflammation) by I and II at 30 min after the injection. In addition, results in histamine-induced rat paw edema showed anti-inflammatory effects of all drugs started 60 min after the injection as these effects continued for a longer period by II and III comparing to I, as discussed above. In addition, the data on vascular permeability in xylene-induced ear edema and acetic acid-induced to peritoneal cavity confirmed that substitutions on CYCLIZINE molecule were more effective and could decrease the vascular permeability and acute inflammation. However, the results from the cotton pellet-induced granuloma formation in rats revealed that none of the drugs (I-III) were effective to reduce the reactions and intermediates of chronic inflammation.

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    APA: Copy

    AHMADI, ABAS, KHALILI, MOHSEN, CHAVROGH, SHAHNAZ, & NAHRI NIKNAFS, BABAK. (2012). SYNTHESIS AND ANTI-INFLAMMATORY PERFORMANCE OF NEWLY CYCLIZINE DERIVATIVES ON ADULT MALE WISTAR RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(4), 1027-1037. SID. https://sid.ir/paper/288018/en

    Vancouver: Copy

    AHMADI ABAS, KHALILI MOHSEN, CHAVROGH SHAHNAZ, NAHRI NIKNAFS BABAK. SYNTHESIS AND ANTI-INFLAMMATORY PERFORMANCE OF NEWLY CYCLIZINE DERIVATIVES ON ADULT MALE WISTAR RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(4):1027-1037. Available from: https://sid.ir/paper/288018/en

    IEEE: Copy

    ABAS AHMADI, MOHSEN KHALILI, SHAHNAZ CHAVROGH, and BABAK NAHRI NIKNAFS, “SYNTHESIS AND ANTI-INFLAMMATORY PERFORMANCE OF NEWLY CYCLIZINE DERIVATIVES ON ADULT MALE WISTAR RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 4, pp. 1027–1037, 2012, [Online]. Available: https://sid.ir/paper/288018/en

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