ROLE OF 5-HYDROXYTRYPTAMINE 1A RECEPTORS IN 6-HYDROXYDOPMAINE-INDUCED CATALEPSY-LIKE IMMOBILIZATION IN RATS: A THERAPEUTIC APPROACH FOR TREATING CATALEPSY OF PARKINSON’S DISEASE

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REYHANI RAD SIAMAK; MOHAJJEL NAYEBI ALIREZA; MAHMOUDI JAVAD; SAMINI MORTEZA; BABAPOUR VAHAB

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:4 Page(s): 1175-1181

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Title

ROLE OF 5-HYDROXYTRYPTAMINE 1A RECEPTORS IN 6-HYDROXYDOPMAINE-INDUCED CATALEPSY-LIKE IMMOBILIZATION IN RATS: A THERAPEUTIC APPROACH FOR TREATING CATALEPSY OF PARKINSON’S DISEASE

Author(s)

Keywords

5-HT1A

6-HYDROXYDOPAMINE

8-OHDPAT

NAN-190

CATALEPSY

Abstract

We have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1A (5-HT1A) receptors, improves motor dysfunctions induced by 6-HYDROXYDOPAMINE (6-OHDA) and haloperidol in rats. The present work extends these findings by investigating the role of 5-HT1A receptors on CATALEPSY-like immobilization in rats, a model of Parkinson’s disease. CATALEPSY was induced by unilateral infusion of 6-OH-dopamine (8 mg/2 mL/rat) into the central region of the substantia nigra, compact part (SNc) and assayed by bar-test method 5, 60, 120 and 180 min after the drugs administration. The involvement of 5-HT1A receptors in 6-OHDA-induced CATALEPSY was studied through intraperitoneal (0.25, 0.5 and 1mg/Kg IP) and intrasubstantia nigra, compact part (10 mg/rat, intra-SNc) injection of 8-hydroxy-2- [di-n-propylamino] tetralin (8-OHDPAT) as well as administration of 1- (2-methoxyphenyl) -4- [4- (2-pthalimmido) butyl] piperazine hydrobromide (0.1, 0.5 and 1 mg/Kg, NAN-190, IP). NAN-190 (1 mg/Kg, IP) and 8-OHDPAT (1 mg/Kg, IP and 10 mg/rat, intra-SNc) increased and decreased 6-OHDA-induced CATALEPSY respectively. In normal (non 6-OHDA-lesioned) rats, NAN-190 (1 mg/Kg, IP) increased the elapsed time in bar-test while 8-OHDPAT did not produce any significant effect. The anticataleptic effect of 8-OHDPAT (1 mg/Kg, IP) was reversed markedly by co-injection with NAN-190 (1 mg/Kg, IP). These findings suggest that 5-HT1A receptors are involved in 6-OHDA-induced CATALEPSY-like immobilization.

Cites

BERBERINE CHLORIDE PRETREATMENT EXHIBITS NEUROPROTECTIVE EFFECT AGAINST 6-HYDROXYDOPAMINE-INDUCED NEURONAL INSULT IN RAT

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APA: Copy

REYHANI RAD, SIAMAK, MOHAJJEL NAYEBI, ALIREZA, MAHMOUDI, JAVAD, SAMINI, MORTEZA, & BABAPOUR, VAHAB. (2012). ROLE OF 5-HYDROXYTRYPTAMINE 1A RECEPTORS IN 6-HYDROXYDOPMAINE-INDUCED CATALEPSY-LIKE IMMOBILIZATION IN RATS: A THERAPEUTIC APPROACH FOR TREATING CATALEPSY OF PARKINSON’S DISEASE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(4), 1175-1181. SID. https://sid.ir/paper/288020/en

Vancouver: Copy

REYHANI RAD SIAMAK, MOHAJJEL NAYEBI ALIREZA, MAHMOUDI JAVAD, SAMINI MORTEZA, BABAPOUR VAHAB. ROLE OF 5-HYDROXYTRYPTAMINE 1A RECEPTORS IN 6-HYDROXYDOPMAINE-INDUCED CATALEPSY-LIKE IMMOBILIZATION IN RATS: A THERAPEUTIC APPROACH FOR TREATING CATALEPSY OF PARKINSON’S DISEASE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(4):1175-1181. Available from: https://sid.ir/paper/288020/en

IEEE: Copy

SIAMAK REYHANI RAD, ALIREZA MOHAJJEL NAYEBI, JAVAD MAHMOUDI, MORTEZA SAMINI, and VAHAB BABAPOUR, “ROLE OF 5-HYDROXYTRYPTAMINE 1A RECEPTORS IN 6-HYDROXYDOPMAINE-INDUCED CATALEPSY-LIKE IMMOBILIZATION IN RATS: A THERAPEUTIC APPROACH FOR TREATING CATALEPSY OF PARKINSON’S DISEASE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 4, pp. 1175–1181, 2012, [Online]. Available: https://sid.ir/paper/288020/en

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