PARTIAL FRACTIONATION OF VENOMS FROM TWO IRANIAN VIPERS, ECHIS CARINATUS AND CERASTES PERSICUS FIELDI AND EVALUATION OF THEIR ANTIPLATELET ACTIVITY

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MEHDIZADEH KASHANI TOKTAM; VATANPOUR HOSSEIN; ZOLFAGHARIAN HOSEIN; HOOSHDAR TEHRANI HASAN; HEIDARI MOHAMMAD HOSSEIN; KOBARFARD FARZAD

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:4 Page(s): 1183-1189

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Title

PARTIAL FRACTIONATION OF VENOMS FROM TWO IRANIAN VIPERS, ECHIS CARINATUS AND CERASTES PERSICUS FIELDI AND EVALUATION OF THEIR ANTIPLATELET ACTIVITY

Author(s)

Keywords

ANTICOAGULANT

ANTIPLATELET AGGREGATION

SNAKE VENOM

ECHIS CARINATUS

CERASTES PERSICUS FIELDI

GEL FILTRATION

Abstract

Platelet aggregation inhibitory effect and ANTICOAGULANT properties of fractions separated from the venoms of CERASTES PERSICUS FIELDI and ECHIS CARINATUS were investigated.The partial fractionation was performed on a Sephadex G-100 column. Two fractions separated from CERASTES PERSICUS FIELDI showed anti platelet aggregation activity on ADP (200 mM) -induced platelet aggregation (ca 80% inhibition). Attempts to measure the ANTIPLATELET AGGREGATION activity of crude ECHIS CARINATUS venom and its fractions were not successful due to the protein coagulation of the plasma samples after the addition of venom. ANTICOAGULANT activities of venoms were also evaluated. Total venom of ECHIS CARINATUS showed anti coagulant activity in PT test, while its fractions showed procoagulant activity.

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APA: Copy

MEHDIZADEH KASHANI, TOKTAM, VATANPOUR, HOSSEIN, ZOLFAGHARIAN, HOSEIN, HOOSHDAR TEHRANI, HASAN, HEIDARI, MOHAMMAD HOSSEIN, & KOBARFARD, FARZAD. (2012). PARTIAL FRACTIONATION OF VENOMS FROM TWO IRANIAN VIPERS, ECHIS CARINATUS AND CERASTES PERSICUS FIELDI AND EVALUATION OF THEIR ANTIPLATELET ACTIVITY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(4), 1183-1189. SID. https://sid.ir/paper/288029/en

Vancouver: Copy

MEHDIZADEH KASHANI TOKTAM, VATANPOUR HOSSEIN, ZOLFAGHARIAN HOSEIN, HOOSHDAR TEHRANI HASAN, HEIDARI MOHAMMAD HOSSEIN, KOBARFARD FARZAD. PARTIAL FRACTIONATION OF VENOMS FROM TWO IRANIAN VIPERS, ECHIS CARINATUS AND CERASTES PERSICUS FIELDI AND EVALUATION OF THEIR ANTIPLATELET ACTIVITY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(4):1183-1189. Available from: https://sid.ir/paper/288029/en

IEEE: Copy

TOKTAM MEHDIZADEH KASHANI, HOSSEIN VATANPOUR, HOSEIN ZOLFAGHARIAN, HASAN HOOSHDAR TEHRANI, MOHAMMAD HOSSEIN HEIDARI, and FARZAD KOBARFARD, “PARTIAL FRACTIONATION OF VENOMS FROM TWO IRANIAN VIPERS, ECHIS CARINATUS AND CERASTES PERSICUS FIELDI AND EVALUATION OF THEIR ANTIPLATELET ACTIVITY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 4, pp. 1183–1189, 2012, [Online]. Available: https://sid.ir/paper/288029/en

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