EFFECT OF D-003, A MIXTURE OF HIGH MOLECULAR WEIGHT ALIPHATIC ACIDS, ON GLUCOCORTICOID- AND LIPOPOLYSACCHARIDES (LPS) -INDUCED OSTEONECROSIS

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NOA MIRIAM; MAS ROSA; VALLE MAIKEL; MENDOZA SARAHI; MENDOZA NILDA

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:4 Page(s): 1201-1208

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Title

EFFECT OF D-003, A MIXTURE OF HIGH MOLECULAR WEIGHT ALIPHATIC ACIDS, ON GLUCOCORTICOID- AND LIPOPOLYSACCHARIDES (LPS) -INDUCED OSTEONECROSIS

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Keywords

D-003

OSTEONECROSIS

GLUCOCORTICOID

LIPOPOLYSACCHARIDES

Abstract

Osteonecrosis (ON) is characterized through the impairment of osseous blood flow thatleads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS) -induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the osteoclast apoptosis. This study investigated the effects of D-003 on corticoid- and LPS-induced ON in rats and rabbits.Corticoid-induced ON: Rats were randomized into five groups. A negative control and four groups treated with prednisolone 6 mg/Kg: a positive control and three treated with D-003 (5, 25 and 200 mg/Kg) for 80 days. All positive controls presented ON areas. D-003 significantly reduced the numbers and proportions of ON lesions, as compared to the positive control group.LPS-induced ON in rabbits: Rabbits were randomized into five groups: a negative control and four injected with a single intra-venous injection of LPS (10 mg/Kg) including a positive control and three with D-003 (5, 25 and 200 mg/Kg) for 30 days. ON was seen in all positive controls. The incidence of ON and the number of ON lesions in the groups treated with D-003 (25 and 200 mg/Kg) was significantly lower compared to the positive controls. LPS injection significantly increased the size of bone marrow fat cells in positive controls and such increase was significantly decreased by D-003. In conclusion, D-003 reduced ON lesions in corticoid-and LPS-induced ON and also the size of bone marrow fat cells in rabbits with LPS.

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APA: Copy

NOA, MIRIAM, MAS, ROSA, VALLE, MAIKEL, MENDOZA, SARAHI, & MENDOZA, NILDA. (2012). EFFECT OF D-003, A MIXTURE OF HIGH MOLECULAR WEIGHT ALIPHATIC ACIDS, ON GLUCOCORTICOID- AND LIPOPOLYSACCHARIDES (LPS) -INDUCED OSTEONECROSIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(4), 1201-1208. SID. https://sid.ir/paper/288036/en

Vancouver: Copy

NOA MIRIAM, MAS ROSA, VALLE MAIKEL, MENDOZA SARAHI, MENDOZA NILDA. EFFECT OF D-003, A MIXTURE OF HIGH MOLECULAR WEIGHT ALIPHATIC ACIDS, ON GLUCOCORTICOID- AND LIPOPOLYSACCHARIDES (LPS) -INDUCED OSTEONECROSIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(4):1201-1208. Available from: https://sid.ir/paper/288036/en

IEEE: Copy

MIRIAM NOA, ROSA MAS, MAIKEL VALLE, SARAHI MENDOZA, and NILDA MENDOZA, “EFFECT OF D-003, A MIXTURE OF HIGH MOLECULAR WEIGHT ALIPHATIC ACIDS, ON GLUCOCORTICOID- AND LIPOPOLYSACCHARIDES (LPS) -INDUCED OSTEONECROSIS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 4, pp. 1201–1208, 2012, [Online]. Available: https://sid.ir/paper/288036/en

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