RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF CLARITHROMYCIN IN HUMAN PLASMA USING AMPEROMETRIC DETECTION: APPLICATION IN PHARMACOKINETIC AND BIOEQUIVALENCE STUDIES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FOROUTAN SEYYED MOHSEN; ZARGHI AFSHIN; SHAFAATI ALIREZA; MADADIAN BABAK; ABOLFATHI FARSHID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:SUPPLEMENT 1 Page(s): 65-69

Download Full-Text

View:

250

Download:

124

Cites:

Information Journal Paper

Title

RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF CLARITHROMYCIN IN HUMAN PLASMA USING AMPEROMETRIC DETECTION: APPLICATION IN PHARMACOKINETIC AND BIOEQUIVALENCE STUDIES

Author(s)

Keywords

CLARITHROMYCIN

PLASMA

HPLC

BIOEQUIVALENCY

PHARMACOKINETIC STUDIES

Abstract

A rapid, sensitive and reproducible HPLC method using amperometric detector was developed and validated for the analysis of CLARITHROMYCIN in human PLASMA. The separation was achieved on a monolithic silica column (MZ- C8 1254.0 mm) using acetonitrile-methanol-potassium dihydrogen phosphate buffer (40: 6: 54, v/v), with pH of 7.5, as the mobilephase at a flow rate of 1.5 mL/min. The assay enables the measurement of CLARITHROMYCIN for therapeutic drug monitoring with a minimum quantification limit of 20 ng/mL. The method involves simple, protein precipitation procedure and analytical recovery was complete. The calibration curve was linear over the concentration range of 0.1-6 mg/mL. The coefficients of variation for inter-day and intra-day assay were found to be less than 6%. This method was used in BIOEQUIVALENCY and PHARMACOKINETIC STUDIES of the test (generic) product 2´500 mg CLARITHROMYCIN tablets, with respect to the reference product.

Cites

No record.

References

No record.

Cite

APA: Copy

FOROUTAN, SEYYED MOHSEN, ZARGHI, AFSHIN, SHAFAATI, ALIREZA, MADADIAN, BABAK, & ABOLFATHI, FARSHID. (2013). RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF CLARITHROMYCIN IN HUMAN PLASMA USING AMPEROMETRIC DETECTION: APPLICATION IN PHARMACOKINETIC AND BIOEQUIVALENCE STUDIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(SUPPLEMENT 1), 65-69. SID. https://sid.ir/paper/288051/en

Vancouver: Copy

FOROUTAN SEYYED MOHSEN, ZARGHI AFSHIN, SHAFAATI ALIREZA, MADADIAN BABAK, ABOLFATHI FARSHID. RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF CLARITHROMYCIN IN HUMAN PLASMA USING AMPEROMETRIC DETECTION: APPLICATION IN PHARMACOKINETIC AND BIOEQUIVALENCE STUDIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(SUPPLEMENT 1):65-69. Available from: https://sid.ir/paper/288051/en

IEEE: Copy

SEYYED MOHSEN FOROUTAN, AFSHIN ZARGHI, ALIREZA SHAFAATI, BABAK MADADIAN, and FARSHID ABOLFATHI, “RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF CLARITHROMYCIN IN HUMAN PLASMA USING AMPEROMETRIC DETECTION: APPLICATION IN PHARMACOKINETIC AND BIOEQUIVALENCE STUDIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. SUPPLEMENT 1, pp. 65–69, 2013, [Online]. Available: https://sid.ir/paper/288051/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops