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Information Journal Paper

Title

TOXICITY OF ARSENIC (III) ON ISOLATED LIVER MITOCHONDRIA: A NEW MECHANISTIC APPROACH

Pages

  121-137

Keywords

ARSENIC (III) 
REACTIVE OXYGEN SPECIES (ROS) 
MITOCHONDRIAL PERMEABILITY TRANSITION (MPT) 

Abstract

 Arsenicexposure mainly through food and water has been shown to be associated with increased incidence of numerous cancers and non-cancer harmful health. It is also used in cancer chemotherapy and treatment of several cancer types due to its apoptogenic effects in the various cancer and normal cell lines. We have already reported that liver is the storage site and important target organ in As (III) toxicity and recently, it has been suggested that hepatic toxicity of arsenic could be resulted from impairment of the liver MITOCHONDRIA. In this study, interaction of As (III) with freshly isolated rat MITOCHONDRIA was investigated. We determined different MITOCHONDRIAl toxicity factors as well as MITOCHONDRIAl sources of ROS formation using specific substrates and inhibitors following addition of As (III) to the MITOCHONDRIA. Our results showed that arsenic (III) increased MITOCHONDRIAl ROS formation, lipid peroxidation and MITOCHONDRIAl membrane potential collapse, cytochrome c release and MITOCHONDRIAl swelling in a concentration dependent manner. Addition of As (III) in to the isolated MITOCHONDRIA, inhibited complexes I and II leading to disruption of MITOCHONDRIAl electron transfer chain, decreased MITOCHONDRIAl ATP content and ROS formation.

Cites

References

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    • Cite

    APA: Copy

    HOSSEINI, MIR JAMAL, SHAKI, FATEMEH, GHAZI KHANSARI, MAHMOUD, & POURAHMAD, JALAL. (2013). TOXICITY OF ARSENIC (III) ON ISOLATED LIVER MITOCHONDRIA: A NEW MECHANISTIC APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(SUPPLEMENT 1), 121-137. SID. https://sid.ir/paper/288054/en

    Vancouver: Copy

    HOSSEINI MIR JAMAL, SHAKI FATEMEH, GHAZI KHANSARI MAHMOUD, POURAHMAD JALAL. TOXICITY OF ARSENIC (III) ON ISOLATED LIVER MITOCHONDRIA: A NEW MECHANISTIC APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(SUPPLEMENT 1):121-137. Available from: https://sid.ir/paper/288054/en

    IEEE: Copy

    MIR JAMAL HOSSEINI, FATEMEH SHAKI, MAHMOUD GHAZI KHANSARI, and JALAL POURAHMAD, “TOXICITY OF ARSENIC (III) ON ISOLATED LIVER MITOCHONDRIA: A NEW MECHANISTIC APPROACH,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. SUPPLEMENT 1, pp. 121–137, 2013, [Online]. Available: https://sid.ir/paper/288054/en

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