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Information Journal Paper

Title

BIOACTIVITY-GUIDED SEPARATION OF AN α-AMYLASE INHIBITOR FLAVONOID FROMSALVIA VIRGATE

Pages

  57-61

Abstract

 It is now believed that the inhibition of carbohydrate hydrolyzing enzymes (CHEs) in the digestive tract can significantly prolong the overall carbohydrate digestion time and decrease the postprandial hyperglycemia after a meal. Therefore, inhibitors of CHEs can be useful therapeutic approaches in the management of DIABETES MELLITUS, especially in the type 2, and complications associated with the disease. In our previous study, the ethanol extract of the aerial parts of SALVIA VIRGATA showed an inhibitory effect on pancreatic α -amylase in-vitro. Bioassay-guided fractionation of the extract using the a -amylase inhibitory assay led to the isolation and identification of an active flavone compound, CHRYSOERIOL. The compound concentration dependently inhibited the a -amylase activity with an IC50 value of 1.27 (1.21-1.33) mM.

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    • Cite

    APA: Copy

    NICKAVAR, BAHMAN, & ABOLHASANI, LEYLA. (2013). BIOACTIVITY-GUIDED SEPARATION OF AN α-AMYLASE INHIBITOR FLAVONOID FROMSALVIA VIRGATE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 57-61. SID. https://sid.ir/paper/288082/en

    Vancouver: Copy

    NICKAVAR BAHMAN, ABOLHASANI LEYLA. BIOACTIVITY-GUIDED SEPARATION OF AN α-AMYLASE INHIBITOR FLAVONOID FROMSALVIA VIRGATE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):57-61. Available from: https://sid.ir/paper/288082/en

    IEEE: Copy

    BAHMAN NICKAVAR, and LEYLA ABOLHASANI, “BIOACTIVITY-GUIDED SEPARATION OF AN α-AMYLASE INHIBITOR FLAVONOID FROMSALVIA VIRGATE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 57–61, 2013, [Online]. Available: https://sid.ir/paper/288082/en

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