COMPARATIVE PHARMACOKINETICS OF LEVOFLOXACIN IN HEALTHY VOLUNTEERS AND IN PATIENTS SUFFERING FROM TYPHOID FEVER

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USMAN MUHAMMAD; ASHRAF MUHAMMAD; KHOKHAR MUHAMMAD IMRAN; ASHIQ BILAL; MASOOD MUHAMMAD IRFAN; AFZAL SHEHRYAR; OMER OVAIS; ALI MOHSIN; QADIR M. IMRAN

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:1 Page(s): 147-154

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Title

COMPARATIVE PHARMACOKINETICS OF LEVOFLOXACIN IN HEALTHY VOLUNTEERS AND IN PATIENTS SUFFERING FROM TYPHOID FEVER

Author(s)

Keywords

PHARMACOKINETICS

LEVOFLOXACIN

TYPHOID FEVER

VOLUNTEERS

HPLC

Abstract

The aim of this study was to characterize the effect of TYPHOID FEVER on pharmacokineticparameters of LEVOFLOXACIN (LF) and compare the pharmacokinetic parameters of the said antibiotic in healthy human VOLUNTEERS and patients with TYPHOID FEVER. Total of 12 subjects were divided into two groups "A" (healthy VOLUNTEERS) and "B" (typhoid patients). Single oral dose of LF 500 mg was given and 5 mL of blood was collected from each subject at 0, 0.25, 0.5, 1, 2, 3, 6, 12, 24, 36 and 72 h. Plasma concentrations of LF were measured by HPLC. Pharmacokinetic parameters were calculated from plasma concentration-time data by using MW/PHARM pharmacological analysis. In healthy VOLUNTEERS, the average pharmacokinetic parameters were as Cmax (6.79 mg/mL), Tmax (1.84 h), T1/2 (10.03 h), Ka (2.23 h-1), AUC (110.09 mgh/mL), Vd (85.84 L), Cl (4.57 L/h) and in typhoid patients were Cmax (6.90 mg/mL), Tmax (1.82 h), T1/2 (9.42 h), Ka (2.21 h-1), AUC (105.55 mgh/mL), Vd (64.31 L), Cl (4.75 L/h). The difference between pharmacokinetic parameters of LF in healthy human VOLUNTEERS and typhoid patients was calculated by using unpaired t-test. As the p-value in case of all pharmacokinetic parameters was more than 0.05, the difference between pharmacokinetic parameters in both healthy human VOLUNTEERS and typhoid patients was insignificant. It is concluded that there is no need to adjust the dose of LF in typhoid patients.

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APA: Copy

USMAN, MUHAMMAD, ASHRAF, MUHAMMAD, KHOKHAR, MUHAMMAD IMRAN, ASHIQ, BILAL, MASOOD, MUHAMMAD IRFAN, AFZAL, SHEHRYAR, OMER, OVAIS, ALI, MOHSIN, & QADIR, M. IMRAN. (2013). COMPARATIVE PHARMACOKINETICS OF LEVOFLOXACIN IN HEALTHY VOLUNTEERS AND IN PATIENTS SUFFERING FROM TYPHOID FEVER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 147-154. SID. https://sid.ir/paper/288087/en

Vancouver: Copy

USMAN MUHAMMAD, ASHRAF MUHAMMAD, KHOKHAR MUHAMMAD IMRAN, ASHIQ BILAL, MASOOD MUHAMMAD IRFAN, AFZAL SHEHRYAR, OMER OVAIS, ALI MOHSIN, QADIR M. IMRAN. COMPARATIVE PHARMACOKINETICS OF LEVOFLOXACIN IN HEALTHY VOLUNTEERS AND IN PATIENTS SUFFERING FROM TYPHOID FEVER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):147-154. Available from: https://sid.ir/paper/288087/en

IEEE: Copy

MUHAMMAD USMAN, MUHAMMAD ASHRAF, MUHAMMAD IMRAN KHOKHAR, BILAL ASHIQ, MUHAMMAD IRFAN MASOOD, SHEHRYAR AFZAL, OVAIS OMER, MOHSIN ALI, and M. IMRAN QADIR, “COMPARATIVE PHARMACOKINETICS OF LEVOFLOXACIN IN HEALTHY VOLUNTEERS AND IN PATIENTS SUFFERING FROM TYPHOID FEVER,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 147–154, 2013, [Online]. Available: https://sid.ir/paper/288087/en

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