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Cites:

1

Information Journal Paper

Title

CYTOTOXICITY OF ICD-85 NPS ON HUMAN CERVICAL CARCINOMA HELA CELLS THROUGH CASPASE-8 MEDIATED PATHWAY

Pages

  155-163

Abstract

 The biological application of NANOPARTICLES (NPs) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human CANCERs. The cytotoxicity was evaluated by MTT and LDH assays. The apoptotic effect of free ICD-85 and ICD-85 NPs on HeLa cells was assessed using CASPASE-8 colorimetric assay. The MTT ASSAY showed that ICD-85 NPs could enhance thein-vitro cytotoxicity against HeLa cells compared to the free ICD-85. The IC50 value at 72 h was reduced from 25 ± 2.9 mg/mL for free ICD-85 to 15.5 ± 2.4 mg/mL for ICD-85 NPs. However, LDH assay demonstrated that ICD-85 has dose-dependent cytotoxicity on HeLa cells while ICD-85 NPs exhibited weaker cytotoxicity on same cells. The results also indicate that ICD-85-induced apoptosis on HeLa cells is associated with the activation of CASPASE-8. Moreover, CASPASE-8 assay analysis demonstrated that the ICD- 85 NPs induced a higher apoptotic rate in HeLa cells compared to free ICD-85. Our results demonstrated that the encapsulation of ICD-85 enhances its anti-proliferative effects. Taken together, these results suggest that the delivery of ICD-85 in NANOPARTICLES may be a promising approach for the treatment of the CANCER.

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    • Cite

    APA: Copy

    MORADHASELI, SAEED, ZARE MIRAKABADI, ABBAS, SARZAEEM, ALI, KAMALZADEH, MORTEZA, & HAJI HOSSEINI, REZA. (2013). CYTOTOXICITY OF ICD-85 NPS ON HUMAN CERVICAL CARCINOMA HELA CELLS THROUGH CASPASE-8 MEDIATED PATHWAY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 155-163. SID. https://sid.ir/paper/288088/en

    Vancouver: Copy

    MORADHASELI SAEED, ZARE MIRAKABADI ABBAS, SARZAEEM ALI, KAMALZADEH MORTEZA, HAJI HOSSEINI REZA. CYTOTOXICITY OF ICD-85 NPS ON HUMAN CERVICAL CARCINOMA HELA CELLS THROUGH CASPASE-8 MEDIATED PATHWAY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):155-163. Available from: https://sid.ir/paper/288088/en

    IEEE: Copy

    SAEED MORADHASELI, ABBAS ZARE MIRAKABADI, ALI SARZAEEM, MORTEZA KAMALZADEH, and REZA HAJI HOSSEINI, “CYTOTOXICITY OF ICD-85 NPS ON HUMAN CERVICAL CARCINOMA HELA CELLS THROUGH CASPASE-8 MEDIATED PATHWAY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 155–163, 2013, [Online]. Available: https://sid.ir/paper/288088/en

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