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Information Journal Paper

Title

LEVEL OF SERUM ENZYMES AND ELECTROCARDIOGRAM IN HEALTHY RABBITS AFTER INJECTION OF ICD-85 AS AN ANTICANCER AGENT

Pages

  206-213

Abstract

 Background: Our previous in vivo studies confirmed that ICD-85, as an ANTICANCER agent, was able to prevent further growth of breast tumors and expand the life expectancy of mice with breast cancer. Methods: Blood collection was carried out before, 1, 3, and 6 hours after ICD-85 injection. Sera were used to determinate the cardio and hepatic enzymes levels, including ALT, AST, LDH, CPK, and Ck-MB. Coagulation factors such as PT and PTT were also assayed. ECGs of all rabbits were recorded during the experiment. Results: ECG results showed that the injection of 50 and 100 mg/kg ICD-85 into healthy rabbits has no significant effect on heart function while the injection of 150 to 200 mg/kg ICD-85 caused ECG wave changes and mild bradycardia without toxic effects on heart. After ICD-85 injection (concentrations below 100 mg/kg), no significant increase was observed in liver and cardiac enzymes (ALT, AST, LDH, CPK, and CK-MB). However, the concentration of 150 mg/kg and above caused a rise in the enzymes. Comparison of the PT and PTT before and after ICD-85 injection showed no significant clotting time at any concentrations below 200 mg/kg. Conclusion: Based on the results obtained in the present study as well as our previous reports, ICD-85 at concentrations below 100 mg/kg seems to have no significant effect on the serum enzymes as indicators of hepatotoxicity and cardio toxicity in healthy rabbits. However, to confirm this conclusion, more detailed surveys on heart and liver is needed to be carried out.

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    Cite

    APA: Copy

    ZARE MIRAKABADI, ABBAS, & SARZAEEM, ALI. (2015). LEVEL OF SERUM ENZYMES AND ELECTROCARDIOGRAM IN HEALTHY RABBITS AFTER INJECTION OF ICD-85 AS AN ANTICANCER AGENT. IRANIAN BIOMEDICAL JOURNAL, 19(4), 206-213. SID. https://sid.ir/paper/277439/en

    Vancouver: Copy

    ZARE MIRAKABADI ABBAS, SARZAEEM ALI. LEVEL OF SERUM ENZYMES AND ELECTROCARDIOGRAM IN HEALTHY RABBITS AFTER INJECTION OF ICD-85 AS AN ANTICANCER AGENT. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(4):206-213. Available from: https://sid.ir/paper/277439/en

    IEEE: Copy

    ABBAS ZARE MIRAKABADI, and ALI SARZAEEM, “LEVEL OF SERUM ENZYMES AND ELECTROCARDIOGRAM IN HEALTHY RABBITS AFTER INJECTION OF ICD-85 AS AN ANTICANCER AGENT,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 4, pp. 206–213, 2015, [Online]. Available: https://sid.ir/paper/277439/en

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