GLUCOSE AND FLUOXETINE INDUCE FINE STRUCTURAL CHANGE IN HUMAN SERUM ALBUMIN

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SHAHANI MINOO; DANESHIMEHR FATEMEH; TADAYON ROYA; HOSEINZADE SALAVATI BEHROOZ; AKBAR ZADEH BAGHBAN ALIREZA; ZAMANIAN ABBAS; REZAEI TAVIRANI MOSTAFA

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:1 Page(s): 185-191

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Title

GLUCOSE AND FLUOXETINE INDUCE FINE STRUCTURAL CHANGE IN HUMAN SERUM ALBUMIN

Author(s)

Keywords

HUMAN SERUM ALBUMIN

GLUCOSE

FLORESCENCE

PH DENATURATION

STRUCTURAL AND FUNCTIONAL ALTERATION

Abstract

HUMAN SERUM ALBUMIN has been used as a model protein for protein folding and ligand binding studies over many decades. Due to its long life period and high concentration in plasma, HSA is highly sensitive to glycation. It is reported that 175 mg/dL GLUCOSE concentration is a threshold of kidney activity for the beginning of excretion of GLUCOSE. PH DENATURATION of HSA in absence and presence of different concentrations of GLUCOSE is studied and based on the Pace two-state model, the findings are analyzed. In addition, FLORESCENCE emission data of albumin range in the period of 300-500 nm was depicted. The amounts of free energy change and [D] 1/2 parameters of unfolding in correspond to FLORESCENCE date indicate that GLUCOSE induces fine structural change in HUMAN SERUM ALBUMIN. Results showed that 175 mg/dL GLUCOSE concentration is a critical point for albumin STRUCTURAL AND FUNCTIONAL ALTERATION.

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APA: Copy

SHAHANI, MINOO, DANESHIMEHR, FATEMEH, TADAYON, ROYA, HOSEINZADE SALAVATI, BEHROOZ, AKBAR ZADEH BAGHBAN, ALIREZA, ZAMANIAN, ABBAS, & REZAEI TAVIRANI, MOSTAFA. (2013). GLUCOSE AND FLUOXETINE INDUCE FINE STRUCTURAL CHANGE IN HUMAN SERUM ALBUMIN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 185-191. SID. https://sid.ir/paper/288089/en

Vancouver: Copy

SHAHANI MINOO, DANESHIMEHR FATEMEH, TADAYON ROYA, HOSEINZADE SALAVATI BEHROOZ, AKBAR ZADEH BAGHBAN ALIREZA, ZAMANIAN ABBAS, REZAEI TAVIRANI MOSTAFA. GLUCOSE AND FLUOXETINE INDUCE FINE STRUCTURAL CHANGE IN HUMAN SERUM ALBUMIN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):185-191. Available from: https://sid.ir/paper/288089/en

IEEE: Copy

MINOO SHAHANI, FATEMEH DANESHIMEHR, ROYA TADAYON, BEHROOZ HOSEINZADE SALAVATI, ALIREZA AKBAR ZADEH BAGHBAN, ABBAS ZAMANIAN, and MOSTAFA REZAEI TAVIRANI, “GLUCOSE AND FLUOXETINE INDUCE FINE STRUCTURAL CHANGE IN HUMAN SERUM ALBUMIN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 185–191, 2013, [Online]. Available: https://sid.ir/paper/288089/en

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