SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL CURCUMIN DERIVATIVES CONTAINING HETEROCYCLIC MOIETY

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HAMED OTHMAN A.; MEHDAWI NOHA; ABU TAHA ADHAM; HAMED EMAD M.; AL NURIA MOHAMMED A.; HUSSEIN AYMAN S.

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:1 Page(s): 47-56

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Title

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL CURCUMIN DERIVATIVES CONTAINING HETEROCYCLIC MOIETY

Author(s)

Keywords

ANTIMICROBIAL ACTIVITY

PYRAZOLES

ISOXAZOLES

DIAZEPINE

DISC DIFFUSION

Abstract

A series of curcumin derivatives containing heterocyclic moiety have been synthesized and evaluated for their antibacterial activities. The chemical structures of the synthesizedcompounds were verified on the basis of spectral data and elemental analyses. Investigation of ANTIMICROBIAL ACTIVITY of the derivatives demonstrated the ability to inhibit Gram-positive microorganisms with zone of inhibition ranging from 14-18 mm, MIC ranging between 0.0625 and 0.25 mg/mL. Among all tested derivatives, DIAZEPINE 4 exhibited remarkable potency against Gram-positive bacteria S. aureus. An extensive study is underway to optimize the effectiveness of DIAZEPINE type of compounds and to determine their mode of action.

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APA: Copy

HAMED, OTHMAN A., MEHDAWI, NOHA, ABU TAHA, ADHAM, HAMED, EMAD M., AL NURIA, MOHAMMED A., & HUSSEIN, AYMAN S.. (2013). SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL CURCUMIN DERIVATIVES CONTAINING HETEROCYCLIC MOIETY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 47-56. SID. https://sid.ir/paper/288097/en

Vancouver: Copy

HAMED OTHMAN A., MEHDAWI NOHA, ABU TAHA ADHAM, HAMED EMAD M., AL NURIA MOHAMMED A., HUSSEIN AYMAN S.. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL CURCUMIN DERIVATIVES CONTAINING HETEROCYCLIC MOIETY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):47-56. Available from: https://sid.ir/paper/288097/en

IEEE: Copy

OTHMAN A. HAMED, NOHA MEHDAWI, ADHAM ABU TAHA, EMAD M. HAMED, MOHAMMED A. AL NURIA, and AYMAN S. HUSSEIN, “SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL CURCUMIN DERIVATIVES CONTAINING HETEROCYCLIC MOIETY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 47–56, 2013, [Online]. Available: https://sid.ir/paper/288097/en

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