MITOCHONDRIAL TOXICITY OF DEPLETED URANIUM: PROTECTION BY BETA-GLUCAN

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SHAKI FATEMEH; POURAHMAD JALAL

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:1 Page(s): 131-140

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Information Journal Paper

Title

MITOCHONDRIAL TOXICITY OF DEPLETED URANIUM: PROTECTION BY BETA-GLUCAN

Author(s)

SHAKI FATEMEH | POURAHMAD JALAL | Issue Writer Certificate

Keywords

DEPLETED URANIUM

BETA-GLUCAN

MITOCHONDRIA

NEPHROTOXICITY

PROTECTION

ANTIOXIDANT

Abstract

Considerable evidence suggests that MITOCHONDRIAl dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of DEPLETED URANIUM (DU). We examined the ability of the two ANTIOXIDANTs, BETA-GLUCAN and butylated hydroxyl toluene (BHT), to prevent UA-induced MITOCHONDRIAl dysfunction using rat-isolated kidney MITOCHONDRIA. BETA-GLUCAN (150 nM) and BHT (20 nM) attenuated UA-induced MITOCHONDRIAl reactive oxygen species (ROS) formation, lipid peroxidation and glutathione oxidation. BETA-GLUCAN and BHT also prevented the loss of MITOCHONDRIAl membrane potential (MMP) and MITOCHONDRIAl swelling following the UA treatment in isolated MITOCHONDRIA. Our results show that BETA-GLUCAN and BHT prevented UA-induced MITOCHONDRIAl outer membrane damage as well as release of cytochrome c from MITOCHONDRIA. UA also decreased the ATP production in isolated MITOCHONDRIA significantly inhibited with BETA-GLUCAN and BHT pre-treatment. Our results showed that BETA-GLUCAN may be MITOCHONDRIA-targeted ANTIOXIDANT and suggested this compound as a possible drug candidate for prophylaxis and treatment against DU-induced NEPHROTOXICITY.

Cites

NANOCERIA ATTENUATED HIGH GLUCOSE-INDUCED OXIDATIVE DAMAGE IN HEPG2 CELLS

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APA: Copy

SHAKI, FATEMEH, & POURAHMAD, JALAL. (2013). MITOCHONDRIAL TOXICITY OF DEPLETED URANIUM: PROTECTION BY BETA-GLUCAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 131-140. SID. https://sid.ir/paper/288100/en

Vancouver: Copy

SHAKI FATEMEH, POURAHMAD JALAL. MITOCHONDRIAL TOXICITY OF DEPLETED URANIUM: PROTECTION BY BETA-GLUCAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):131-140. Available from: https://sid.ir/paper/288100/en

IEEE: Copy

FATEMEH SHAKI, and JALAL POURAHMAD, “MITOCHONDRIAL TOXICITY OF DEPLETED URANIUM: PROTECTION BY BETA-GLUCAN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 131–140, 2013, [Online]. Available: https://sid.ir/paper/288100/en

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