THE EFFECT OF VITIS VINIFERA L. LEAVES EXTRACT ON LEISHMANIA INFANTUM

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MANSOUR RYM; HAOUAS NAJOUA; KAHLA NAKBI AMEL BEN; HAMMAMI SAOUSSEN; MIGHRI ZINE; MHENNI FAROUK; BABBA HAMOUDA

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:3 Page(s): 349-355

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Title

THE EFFECT OF VITIS VINIFERA L. LEAVES EXTRACT ON LEISHMANIA INFANTUM

Author(s)

Keywords

VITIS VINIFERA L.

EXTRACTION

LEISHMANIASIS

ANTILEISHMANIAL ACTIVITY

ANTHOCYANINS

Abstract

VITIS VINIFERA L.is a traditional Asian herb widely used for different health problems. In the present research, the ethanolic and the aqueous extracts of VITIS VINIFERA L. leaves collected from shrub, grown in Tunisia, were prepared and evaluated for the ANTILEISHMANIAL ACTIVITY against Leishmani ainfantum promastigotes. The inhibitory concentration 50 (IC50) was determined and the results showed that the etahnolic extract is more active than the aqueous one (IC50= 0.108 mg/mL). Microscopic observations showed that the ethanolic extract promoted the destruction of cytoplasmic and nuclear membranes of Leishmani ainfantum promastigotes and altered the overall shape of the cell. In order to explain the difference of ANTILEISHMANIAL ACTIVITY between ethanolic and aqueous extracts, ANTHOCYANINS amount was determined by spectrophotometry. It was found that the ethanolic extract is richer in ANTHOCYANINS than the aqueous one which can explain the higher ANTILEISHMANIAL ACTIVITY of the ethanolic extract.

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APA: Copy

MANSOUR, RYM, HAOUAS, NAJOUA, KAHLA NAKBI, AMEL BEN, HAMMAMI, SAOUSSEN, MIGHRI, ZINE, MHENNI, FAROUK, & BABBA, HAMOUDA. (2013). THE EFFECT OF VITIS VINIFERA L. LEAVES EXTRACT ON LEISHMANIA INFANTUM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(3), 349-355. SID. https://sid.ir/paper/288112/en

Vancouver: Copy

MANSOUR RYM, HAOUAS NAJOUA, KAHLA NAKBI AMEL BEN, HAMMAMI SAOUSSEN, MIGHRI ZINE, MHENNI FAROUK, BABBA HAMOUDA. THE EFFECT OF VITIS VINIFERA L. LEAVES EXTRACT ON LEISHMANIA INFANTUM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(3):349-355. Available from: https://sid.ir/paper/288112/en

IEEE: Copy

RYM MANSOUR, NAJOUA HAOUAS, AMEL BEN KAHLA NAKBI, SAOUSSEN HAMMAMI, ZINE MIGHRI, FAROUK MHENNI, and HAMOUDA BABBA, “THE EFFECT OF VITIS VINIFERA L. LEAVES EXTRACT ON LEISHMANIA INFANTUM,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 3, pp. 349–355, 2013, [Online]. Available: https://sid.ir/paper/288112/en

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