IN-VITRO COMPARISON OF CYTOTOXICITY OF TWO BIOACTIVE GLASSES IN MICROPOWDER AND NANOPOWDER FORMS

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RISMANCHIAN MANSOUR; KHODAEIAN NILOFAR; BAHRAMIAN LIDA; FATHI MOHAMMAD HOSSEIN; SADEGHI ALIABADI HOJJAT

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:3 Page(s): 437-443

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Title

IN-VITRO COMPARISON OF CYTOTOXICITY OF TWO BIOACTIVE GLASSES IN MICROPOWDER AND NANOPOWDER FORMS

Author(s)

Keywords

MICROPOWDER

NANOPOWDER

MTT ASSAY

HGF1-P153 CELL LINE

Abstract

The cytotoxicity of the biomaterials is a key issue that should be addressed prior to preclinical applications. This study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses: NANOPOWDER and MICROPOWDER. Human HGF1-PI53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ mL concentrations of the two bioactive glasses via MTT ASSAY. The results were statistically analyzed using analysis of variance and Tukey’s test. A p-value less than 0.05 was considered statistically significant. Results showed that two bioactive glasses had statistically significant differences at 5, 10, 15 and 20 mg/mL concentrations (p-value < 0.05) and there was no correlation between time and cell cytotoxicity of bioactive glasses (p-value > 0.05), using t-test and Spearman’s correlation coefficient. We conclude that that cytotoxicity of NANOPOWDER bioactive glass at concentrations £ 2 mg/mL was similar to MICROPOWDER bioactive glass at 24 and 48 h, however, it is more cytotoxic at concentrations ³ 5 mg/mL in the first 48 h of applications.

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APA: Copy

RISMANCHIAN, MANSOUR, KHODAEIAN, NILOFAR, BAHRAMIAN, LIDA, FATHI, MOHAMMAD HOSSEIN, & SADEGHI ALIABADI, HOJJAT. (2013). IN-VITRO COMPARISON OF CYTOTOXICITY OF TWO BIOACTIVE GLASSES IN MICROPOWDER AND NANOPOWDER FORMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(3), 437-443. SID. https://sid.ir/paper/288128/en

Vancouver: Copy

RISMANCHIAN MANSOUR, KHODAEIAN NILOFAR, BAHRAMIAN LIDA, FATHI MOHAMMAD HOSSEIN, SADEGHI ALIABADI HOJJAT. IN-VITRO COMPARISON OF CYTOTOXICITY OF TWO BIOACTIVE GLASSES IN MICROPOWDER AND NANOPOWDER FORMS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(3):437-443. Available from: https://sid.ir/paper/288128/en

IEEE: Copy

MANSOUR RISMANCHIAN, NILOFAR KHODAEIAN, LIDA BAHRAMIAN, MOHAMMAD HOSSEIN FATHI, and HOJJAT SADEGHI ALIABADI, “IN-VITRO COMPARISON OF CYTOTOXICITY OF TWO BIOACTIVE GLASSES IN MICROPOWDER AND NANOPOWDER FORMS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 3, pp. 437–443, 2013, [Online]. Available: https://sid.ir/paper/288128/en

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