IN-VITRO ACTIVITY OF 10 ANTIFUNGAL AGENTS AGAINST 320 DERMATOPHYTE STRAINS USING MICRODILUTION METHOD IN TEHRAN

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ADIMI PARVANEH; HASHEMI SEYED JAMAL; MAHMOUDI MAHMOOD; MIRHENDI HOSSEIN; SHIDFAR MOHAMMAD REZA; EMAMI MASOUD; REZAEI MATEHKOLAEI ALI; GERAMI SHOAR MOHSEN; KORDBACHEH PARIVASH

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:3 Page(s): 537-545

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Title

IN-VITRO ACTIVITY OF 10 ANTIFUNGAL AGENTS AGAINST 320 DERMATOPHYTE STRAINS USING MICRODILUTION METHOD IN TEHRAN

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Abstract

Dermatophyte fungi are the etiologic agents of skin infections commonly referred to as ringworm. These infections are not dangerous but as a chronic cutaneous infections they may be difficult to treat and can also cause physical discomfort for patients. They are considered important as a public health problem as well. No information is available regarding the efficacy of antifungal agents against dermatophytes in Tehran. Therefore, in this study we evaluated the efficacy of 10 systemic and topical antifungal medications using CLSI broth microdilution method (M38-A). The antifungal agents used included griseofulvin, terbinafine, itraconazole, ketoconazole, fluconazole, voriconazole, clotrimazole, ciclopirox olamine, amorolfine and naftifine. Fifteen different species of dermatophytes which were mostly clinical isolates were used as follows; T. mentagrophytes, T. rubrum, E. floccosum, M. canis, T. verrucosum, T. tonsurans, M. gypseum, T. violaceum, M. ferruginum, M. fulvum, T. schoenleinii, M. racemosum, T. erinacei, T. eriotrephon and Arthroderma benhamiae. The mean number of fungi particles (conidia) inoculated was 1.25 ´ 104 CFU/mL. Results were read after 7 days of incubation at 28oC. According to the obtained results, itraconazole and terbinafine showed the lowest and fluconazole had the greatest MIC values for the most fungi tested. Based on the results, it is necessary to do more research and design a reliable standard method for determination of antifungal susceptibility to choose proper antibiotics with fewer side effects and decrease antifungal resistance and risk of treatment failure.

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APA: Copy

ADIMI, PARVANEH, HASHEMI, SEYED JAMAL, MAHMOUDI, MAHMOOD, MIRHENDI, HOSSEIN, SHIDFAR, MOHAMMAD REZA, EMAMI, MASOUD, REZAEI MATEHKOLAEI, ALI, GERAMI SHOAR, MOHSEN, & KORDBACHEH, PARIVASH. (2013). IN-VITRO ACTIVITY OF 10 ANTIFUNGAL AGENTS AGAINST 320 DERMATOPHYTE STRAINS USING MICRODILUTION METHOD IN TEHRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(3), 537-545. SID. https://sid.ir/paper/288136/en

Vancouver: Copy

ADIMI PARVANEH, HASHEMI SEYED JAMAL, MAHMOUDI MAHMOOD, MIRHENDI HOSSEIN, SHIDFAR MOHAMMAD REZA, EMAMI MASOUD, REZAEI MATEHKOLAEI ALI, GERAMI SHOAR MOHSEN, KORDBACHEH PARIVASH. IN-VITRO ACTIVITY OF 10 ANTIFUNGAL AGENTS AGAINST 320 DERMATOPHYTE STRAINS USING MICRODILUTION METHOD IN TEHRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(3):537-545. Available from: https://sid.ir/paper/288136/en

IEEE: Copy

PARVANEH ADIMI, SEYED JAMAL HASHEMI, MAHMOOD MAHMOUDI, HOSSEIN MIRHENDI, MOHAMMAD REZA SHIDFAR, MASOUD EMAMI, ALI REZAEI MATEHKOLAEI, MOHSEN GERAMI SHOAR, and PARIVASH KORDBACHEH, “IN-VITRO ACTIVITY OF 10 ANTIFUNGAL AGENTS AGAINST 320 DERMATOPHYTE STRAINS USING MICRODILUTION METHOD IN TEHRAN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 3, pp. 537–545, 2013, [Online]. Available: https://sid.ir/paper/288136/en

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