GABAPENTIN DETERMINATION IN HUMAN PLASMA AND CAPSULE BY COUPLING OF SOLID PHASE EXTRACTION, DERIVATIZATION REACTION, AND UV-VIS SPECTROPHOTOMETRY

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KAZEMIPOUR MARYAM; FAKHARI IMAN; ANSARI MEHDI

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:3 Page(s): 247-253

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Information Journal Paper

Title

GABAPENTIN DETERMINATION IN HUMAN PLASMA AND CAPSULE BY COUPLING OF SOLID PHASE EXTRACTION, DERIVATIZATION REACTION, AND UV-VIS SPECTROPHOTOMETRY

Author(s)

KAZEMIPOUR MARYAM | FAKHARI IMAN | ANSARI MEHDI | Issue Writer Certificate

Keywords

GABAPENTIN

SPECTROPHOTOMETRY

DERIVATIZATION

SPE

PLASMA

VANILLIN

Abstract

GABAPENTIN is an anticonvulsant widely used in the treatment of epilepsy. No peculiar chromophore is available on the GABAPENTIN moiety for direct analysis by absorption SPECTROPHOTOMETRY/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> SPECTROPHOTOMETRY. A sensitive SPEctrophotometric method for the determination of GABAPENTIN in bulk, pharmaceutical formulations and human PLASMA has been developed. In this method, GABAPENTIN directly derivatized with VANILLIN and analyzed without any extraction in bulk and pharmaceutical dosage form and in PLASMA samples, it was extracted with a reversed-phase solid-phase extraction (SPE) cartridge followed by DERIVATIZATION with VANILLIN. Analysis was performed by a SPEctrophotometer system. The quantitation limit of GABAPENTIN in human PLASMA was 0.8 mg/L. The method was linear over the concentration range of 10.0-90.0 mg/L and 0.8-10.0 mg/L for pharmaceutical dosage form and PLASMA, respectively. The method was precise (relative standard deviation, RSD <1.20%) and accurate (relative mean error <5.5%) for both pharmaceutical dosage form and PLASMA samples. Mean absolute recoveries were 94.5% for PLASMA.

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APA: Copy

KAZEMIPOUR, MARYAM, FAKHARI, IMAN, & ANSARI, MEHDI. (2013). GABAPENTIN DETERMINATION IN HUMAN PLASMA AND CAPSULE BY COUPLING OF SOLID PHASE EXTRACTION, DERIVATIZATION REACTION, AND UV-VIS SPECTROPHOTOMETRY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(3), 247-253. SID. https://sid.ir/paper/288139/en

Vancouver: Copy

KAZEMIPOUR MARYAM, FAKHARI IMAN, ANSARI MEHDI. GABAPENTIN DETERMINATION IN HUMAN PLASMA AND CAPSULE BY COUPLING OF SOLID PHASE EXTRACTION, DERIVATIZATION REACTION, AND UV-VIS SPECTROPHOTOMETRY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(3):247-253. Available from: https://sid.ir/paper/288139/en

IEEE: Copy

MARYAM KAZEMIPOUR, IMAN FAKHARI, and MEHDI ANSARI, “GABAPENTIN DETERMINATION IN HUMAN PLASMA AND CAPSULE BY COUPLING OF SOLID PHASE EXTRACTION, DERIVATIZATION REACTION, AND UV-VIS SPECTROPHOTOMETRY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 3, pp. 247–253, 2013, [Online]. Available: https://sid.ir/paper/288139/en

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