SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 1,3,4-OXADIAZOLE DERIVATIVES

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SINGH ARVIND KUMAR; LOHANI M.; PARTHSARTHY R.

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:2 Page(s): 319-323

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Information Journal Paper

Title

SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 1,3,4-OXADIAZOLE DERIVATIVES

Author(s)

SINGH ARVIND KUMAR | LOHANI M. | PARTHSARTHY R. | Issue Writer Certificate

Keywords

4-OXADIAZOLES

ANTI-INFLAMMATORY

SYNTHESIS

HETEROCYCLIC

Abstract

A series of five-membered HETEROCYCLIC rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1-C7) compounds and was tested for their ANTI-INFLAMMATORY activity determined by rat-paw-oedema method. All the SYNTHESIS compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified by column chromatography. All synthesized derivatives were determined by the carrageenan-induced rat-paw-oedema model for ANTI-INFLAMMATORY activity. The entire compound gives good response for the ANTI-INFLAMMATORY activity: [3-Chloro-N-[5-(3-Chloro-phenyl)-[1,3,4] oxadiazole-2yl] benzamide (C4), and [4-Nitro-N-[5- (4-Nitro-phenyl)-[1,3,4] oxadiazole-2yl] benzamide (C7). For this activity, indometacin was used as a standard drug and compared to new synthesized drugs. Some new synthesized drugs have shown better activities for the anti-inflammation.

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APA: Copy

SINGH, ARVIND KUMAR, LOHANI, M., & PARTHSARTHY, R.. (2013). SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 1,3,4-OXADIAZOLE DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 319-323. SID. https://sid.ir/paper/288147/en

Vancouver: Copy

SINGH ARVIND KUMAR, LOHANI M., PARTHSARTHY R.. SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 1,3,4-OXADIAZOLE DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):319-323. Available from: https://sid.ir/paper/288147/en

IEEE: Copy

ARVIND KUMAR SINGH, M. LOHANI, and R. PARTHSARTHY, “SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME 1,3,4-OXADIAZOLE DERIVATIVES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 319–323, 2013, [Online]. Available: https://sid.ir/paper/288147/en

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