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Information Journal Paper

Title

SYNTHESIS AND ANTIDIABETIC EVALUATION OF BENZENESULFONAMIDE DERIVATIVES

Pages

  320-330

Abstract

 The complex metabolic syndrome, DIABETES MELLITUS, is a major human health concern in the world and is estimated to affect 300 million people by the year 2025. Several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycemia in DIABETES MELLITUS. These drugs have side effects and thus searching for a new class of compounds is essential to overcome this problems.A series of seven novel N-(4-phenylthiazol-2-yl) BENZENESULFONAMIDES derivatives were synthesized and assayed in-vivo to investigate their antidiabetic activities by streptozotocin-induced model in rat. These derivatives showed considerable biological efficacy when compared to glibenclamide, a potent and well-known antidiabetic agent, as a reference drug. Four of the compounds were effective, amongst which 13 show more prominent activity at 100 mg/Kg p.o. The experimental results are statistically significant at p<0.05 level.

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    APA: Copy

    HOSSEINZADEH, NOURADDIN, SERAJ, SOODEH, BAKHSHI DEZFFOLI, MOHAMAD EBRAHIM, HASANI, MOHAMMAD, KHOSHNEVISZADEH, MEHDI, FALLAH BONEKOHAL, SAEED, ABDOLLAHI, MOHAMMAD, FOROUMADI, ALIREZA, & SHAFIEE, ABBAS. (2013). SYNTHESIS AND ANTIDIABETIC EVALUATION OF BENZENESULFONAMIDE DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 320-330. SID. https://sid.ir/paper/288161/en

    Vancouver: Copy

    HOSSEINZADEH NOURADDIN, SERAJ SOODEH, BAKHSHI DEZFFOLI MOHAMAD EBRAHIM, HASANI MOHAMMAD, KHOSHNEVISZADEH MEHDI, FALLAH BONEKOHAL SAEED, ABDOLLAHI MOHAMMAD, FOROUMADI ALIREZA, SHAFIEE ABBAS. SYNTHESIS AND ANTIDIABETIC EVALUATION OF BENZENESULFONAMIDE DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):320-330. Available from: https://sid.ir/paper/288161/en

    IEEE: Copy

    NOURADDIN HOSSEINZADEH, SOODEH SERAJ, MOHAMAD EBRAHIM BAKHSHI DEZFFOLI, MOHAMMAD HASANI, MEHDI KHOSHNEVISZADEH, SAEED FALLAH BONEKOHAL, MOHAMMAD ABDOLLAHI, ALIREZA FOROUMADI, and ABBAS SHAFIEE, “SYNTHESIS AND ANTIDIABETIC EVALUATION OF BENZENESULFONAMIDE DERIVATIVES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 320–330, 2013, [Online]. Available: https://sid.ir/paper/288161/en

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