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Information Journal Paper

Title

EFFECTS OF AQUEOUS EXTRACT OF BERBERIS INTEGERRIMA ROOT ON SOME PHYSIOLOGICAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Pages

  425-434

Abstract

 Diabetes mellitus is a common endocrine disorder. Anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. BERBERIS INTEGERRIMA is a medicinal shrub used in conventional therapy for a number of diseases. The aim of the present study was to investigate the effects of aqueous extract of BERBERIS INTEGERRIMA root (AEBI) on some physiological parameters in normal and STREPTOZOTOCIN-induced (STZ-induced) diabetic male Wistar rats. STZ-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides (TG), total cholesterol (TC), low density lipoprotein LDL-cholesterol (LDL-C), creatinine (Cr), urea, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin while body weight, high density lipoprotein HDL-cholesterol (HDL-C) and total protein levels were significantly decreased compared to normal rats. Treatment of diabetic rats with different doses of aqueous extract of BERBERIS INTEGERRIMA root (250 and 500 mg/Kg bw) resulted in a significant decrease in blood glucose, triglycerides, cholesterol, LDL-cholesterol, ALT, AST, ALP, total bilirubin, creatinine and urea while HDL-cholesterol and total protein levels were markedly increased after six weeks compared to untreated diabetic rats. The effects of the AEBI at dose of 500 mg/Kg in all parameters except blood glucose (similar) is more than to the standard drug, glibenclamide (0.6 mg/Kg, p.o.). The results of this study indicate that the tested aqueous extract of BERBERIS INTEGERRIMA root possesses HYPOGLYCEMIC, HYPOLIPIDEMIC and ANTIOXIDANT effects in STZ-induced diabetic rats.

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    APA: Copy

    ASHRAF, HOSSEIN, HEIDARI, REZA, NEJATI, VAHID, & ILKHANIPOOR, MINOO. (2013). EFFECTS OF AQUEOUS EXTRACT OF BERBERIS INTEGERRIMA ROOT ON SOME PHYSIOLOGICAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 425-434. SID. https://sid.ir/paper/288164/en

    Vancouver: Copy

    ASHRAF HOSSEIN, HEIDARI REZA, NEJATI VAHID, ILKHANIPOOR MINOO. EFFECTS OF AQUEOUS EXTRACT OF BERBERIS INTEGERRIMA ROOT ON SOME PHYSIOLOGICAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):425-434. Available from: https://sid.ir/paper/288164/en

    IEEE: Copy

    HOSSEIN ASHRAF, REZA HEIDARI, VAHID NEJATI, and MINOO ILKHANIPOOR, “EFFECTS OF AQUEOUS EXTRACT OF BERBERIS INTEGERRIMA ROOT ON SOME PHYSIOLOGICAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 425–434, 2013, [Online]. Available: https://sid.ir/paper/288164/en

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