2-AMINO-4- (NITROALKYL) -4H-CHROMENE-3-CARBONITRILES AS NEW CYTOTOXIC AGENTS

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ZONOUZI AFSANEH; MIRZAZADEH ROGHIEH; SAFAVI MALIHEH; KABUDANIAN ARDESTANI SUSSAN; EMAMI SAEID; FOROUMADI ALIREZA

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:4 Page(s): 679-685

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Title

2-AMINO-4- (NITROALKYL) -4H-CHROMENE-3-CARBONITRILES AS NEW CYTOTOXIC AGENTS

Author(s)

Keywords

4H-CHROMENES

BENZOPYRAN

DBU

ONE-POT SYNTHESIS

CYTOTOXIC ACTIVITY

Abstract

A series of 2-amino-4- (nitroalkyl) -4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The CYTOTOXIC ACTIVITY of target compounds were evaluated against three cancer cell lines MDA-MB-231, MCF-7 and T47D in comparison with etoposide as reference drug. Generally, all compounds showed good cell growth inhibitory activity with IC50 values less than 30 mg/mL. Their activities were comparable or more potent than standard drug etoposide. The 6-bromo- derivatives 7e and 7f showed promising CYTOTOXIC ACTIVITY with IC50 values in the range of 3.46-18.76 mg/mL, being more potent than etoposide against all tested cell lines.

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Cites

NOVEL N-2-(FURYL)-2-(CHLOROBENZYLOXYIMINO) ETHYL PIPERAZINYL QUINOLONES: SYNTHESIS, CYTOTOXIC EVALUATION AND STRUCTURE-ACTIVITY RELATIONSHIP

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APA: Copy

ZONOUZI, AFSANEH, MIRZAZADEH, ROGHIEH, SAFAVI, MALIHEH, KABUDANIAN ARDESTANI, SUSSAN, EMAMI, SAEID, & FOROUMADI, ALIREZA. (2013). 2-AMINO-4- (NITROALKYL) -4H-CHROMENE-3-CARBONITRILES AS NEW CYTOTOXIC AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(4), 679-685. SID. https://sid.ir/paper/288209/en

Vancouver: Copy

ZONOUZI AFSANEH, MIRZAZADEH ROGHIEH, SAFAVI MALIHEH, KABUDANIAN ARDESTANI SUSSAN, EMAMI SAEID, FOROUMADI ALIREZA. 2-AMINO-4- (NITROALKYL) -4H-CHROMENE-3-CARBONITRILES AS NEW CYTOTOXIC AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(4):679-685. Available from: https://sid.ir/paper/288209/en

IEEE: Copy

AFSANEH ZONOUZI, ROGHIEH MIRZAZADEH, MALIHEH SAFAVI, SUSSAN KABUDANIAN ARDESTANI, SAEID EMAMI, and ALIREZA FOROUMADI, “2-AMINO-4- (NITROALKYL) -4H-CHROMENE-3-CARBONITRILES AS NEW CYTOTOXIC AGENTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 4, pp. 679–685, 2013, [Online]. Available: https://sid.ir/paper/288209/en

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