مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

424
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

122
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

SYSTEMATIC ANALYSIS OF MAIN CONSTITUENTS IN RAT BIOLOGICAL SAMPLES AFTER ORAL ADMINISTRATION OF THE METHANOL EXTRACT OF FRUCTUS AURANTII BY HPLC-ESI-MS/MS

Pages

  493-503

Abstract

 High performance liquid chromatography (HPLC) with diode array detection (DAD) and electrospray ionization tandem mass spectrometry (ESI/MS/MS) was used to analyze the main components in the methanol extract of FRUCTUS AURANTII (FA) and the METABOLITES in rat biological samples after oral administration of the methanol extract of FA. There were 31 constituents identified in the extract of FA including 2 alkaloids, 1 coumarin, 10 flavonoid glycosides and 18 ploymethoxylated flavones. According to the UV spectrum and MS fragment character of main components in the methanol extract of FA, 18 parent constituents and 11 METABOLITES were tentatively identified in rat biological samples. Three groups of components in biological samples detected included flavonoid glycosides, their glucuronides and ploymethoxylated flavones. It was interested that flavonoid glycosides, their glucuronides and ploymethoxylated flavones can be investigated in rat PLASMA and urine, while in rat feces samples only flavonoid glycosides were detected. Triglycosyl, naringenin, neoeriocitrin, neoeriocitrin narirutin and hesperidin were the main components in rat feces which were found either in the PLASMA or in urine samples. However, naringin and neohesperidin were the main flavonoid glycosides which absorbed after oral administration. Except flavonoid glycosides and their glucuronides, ploymethoxylated flavones also the constituents absorbed because it was investigated mainly in rat PLASMA and urine but not in feces samples. The identification and elucidation of parent and metabolism components analyzed in biological samples provided the data for further pharmacological and clinical research on FA.

Cites

  • No record.
  • References

  • No record.
  • Cite

    APA: Copy

    ZHANG, JINGZE, GAO, WENYUAN, LIU, ZHEN, ZHANG, ZHIDAN, & LIU, CHANGXIAO. (2014). SYSTEMATIC ANALYSIS OF MAIN CONSTITUENTS IN RAT BIOLOGICAL SAMPLES AFTER ORAL ADMINISTRATION OF THE METHANOL EXTRACT OF FRUCTUS AURANTII BY HPLC-ESI-MS/MS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 493-503. SID. https://sid.ir/paper/288218/en

    Vancouver: Copy

    ZHANG JINGZE, GAO WENYUAN, LIU ZHEN, ZHANG ZHIDAN, LIU CHANGXIAO. SYSTEMATIC ANALYSIS OF MAIN CONSTITUENTS IN RAT BIOLOGICAL SAMPLES AFTER ORAL ADMINISTRATION OF THE METHANOL EXTRACT OF FRUCTUS AURANTII BY HPLC-ESI-MS/MS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):493-503. Available from: https://sid.ir/paper/288218/en

    IEEE: Copy

    JINGZE ZHANG, WENYUAN GAO, ZHEN LIU, ZHIDAN ZHANG, and CHANGXIAO LIU, “SYSTEMATIC ANALYSIS OF MAIN CONSTITUENTS IN RAT BIOLOGICAL SAMPLES AFTER ORAL ADMINISTRATION OF THE METHANOL EXTRACT OF FRUCTUS AURANTII BY HPLC-ESI-MS/MS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 493–503, 2014, [Online]. Available: https://sid.ir/paper/288218/en

    Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button