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Information Journal Paper

Title

GC-FID AND HPLC-DAD METHODS FOR THE DETERMINATION OF MENADIONE SODIUM BISULPHITE DIRECTLY AND BY CONVERTING MENADIONE SODIUM BISULPHITE TO MENADIONE IN PHARMACEUTICAL PREPARATION

Pages

  353-364

Abstract

 GC-FID and HPLC-DAD methods were developed for determination of MENADIONE (MN) and MENADIONE sodium bisulphite (MSB). By means of each method, quantitative analysis of MSB in commercial PHARMACEUTICAL was performed in both direct analysis of MSB and analysis of MN by converting MSB to MN with sodium carbonate. GC-FID method was carried out on the HP-5 capillary column using nitrogen gas. HPLC-DAD method was achieved on the reversed phase C8 column by using a mobile phase consisting methanol and water. The calibration curves of GC-FID and HPLC-DAD for both analytes were linear in the same concentration range (0.5–20 mg/mL). Both methods were validated in terms of precision, accuracy, recovery and limits of detection (LOD) and quantitation (LOQ). Although LOD values of HPLC-DAD method (0.010 mg/mL for MN and 0.005 mg/mL for MSB) is lower than obtained values with GC-FID method (0.04 mg/mL for MN and 0.06 mg/mL for MSB), both methods gave similar and favorable results in terms of precision and accuracy. The Student’s t-test was applied to investigate the significant of the different between the results of MSB determination with direct analysis of MSB and analysis of MN by converting MSB to MN by means of GC-FID and HPLC-DAD method in dosage form.

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    • Cite

    APA: Copy

    DEMIRKAYA MILOGLU, FATMA, KADIOGLU, YUCEL, & SENOL, ONUR. (2014). GC-FID AND HPLC-DAD METHODS FOR THE DETERMINATION OF MENADIONE SODIUM BISULPHITE DIRECTLY AND BY CONVERTING MENADIONE SODIUM BISULPHITE TO MENADIONE IN PHARMACEUTICAL PREPARATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 353-364. SID. https://sid.ir/paper/288222/en

    Vancouver: Copy

    DEMIRKAYA MILOGLU FATMA, KADIOGLU YUCEL, SENOL ONUR. GC-FID AND HPLC-DAD METHODS FOR THE DETERMINATION OF MENADIONE SODIUM BISULPHITE DIRECTLY AND BY CONVERTING MENADIONE SODIUM BISULPHITE TO MENADIONE IN PHARMACEUTICAL PREPARATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):353-364. Available from: https://sid.ir/paper/288222/en

    IEEE: Copy

    FATMA DEMIRKAYA MILOGLU, YUCEL KADIOGLU, and ONUR SENOL, “GC-FID AND HPLC-DAD METHODS FOR THE DETERMINATION OF MENADIONE SODIUM BISULPHITE DIRECTLY AND BY CONVERTING MENADIONE SODIUM BISULPHITE TO MENADIONE IN PHARMACEUTICAL PREPARATION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 353–364, 2014, [Online]. Available: https://sid.ir/paper/288222/en

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