EVALUATION OF CYP2C9 ACTIVITY IN RATS: USE OF TOLBUTAMIDE ALONE AND IN COMBINED WITH BUPROPION

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QIU XIANGJUN; SONG JIJUN; YUAN HONGCHANG; HOU YI; PAN XIAOFENG; XU REN AI

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:2 Page(s): 635-639

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Title

EVALUATION OF CYP2C9 ACTIVITY IN RATS: USE OF TOLBUTAMIDE ALONE AND IN COMBINED WITH BUPROPION

Author(s)

Keywords

TOLBUTAMIDE

BUPROPION

P450

PROBE DRUG

COCKTAIL

INTERACTION

Abstract

A "cocktail"of several PROBE DRUGs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some INTERACTIONs among PROBE DRUGs can appear and may impact the rate of biotransformation of other ones. Our presented work was aimed on the influence of BUPROPION on cytochrome P450-mediated metabolism of TOLBUTAMIDE. The biotransformation rates of TOLBUTAMIDE administered either separately or in combined with BUPROPION were compared in this study. The results revealed that BUPROPION had no significant effect on TOLBUTAMIDE hydroxylation. Thus, due to stability in cytochrome P450 enzyme metabolic activity in the case of combining of two model PROBE DRUGs the procedure can show to no extent differential results comparing to the single-marker use.

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APA: Copy

QIU, XIANGJUN, SONG, JIJUN, YUAN, HONGCHANG, HOU, YI, PAN, XIAOFENG, & XU, REN AI. (2014). EVALUATION OF CYP2C9 ACTIVITY IN RATS: USE OF TOLBUTAMIDE ALONE AND IN COMBINED WITH BUPROPION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 635-639. SID. https://sid.ir/paper/288225/en

Vancouver: Copy

QIU XIANGJUN, SONG JIJUN, YUAN HONGCHANG, HOU YI, PAN XIAOFENG, XU REN AI. EVALUATION OF CYP2C9 ACTIVITY IN RATS: USE OF TOLBUTAMIDE ALONE AND IN COMBINED WITH BUPROPION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):635-639. Available from: https://sid.ir/paper/288225/en

IEEE: Copy

XIANGJUN QIU, JIJUN SONG, HONGCHANG YUAN, YI HOU, XIAOFENG PAN, and REN AI XU, “EVALUATION OF CYP2C9 ACTIVITY IN RATS: USE OF TOLBUTAMIDE ALONE AND IN COMBINED WITH BUPROPION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 635–639, 2014, [Online]. Available: https://sid.ir/paper/288225/en

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