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Information Journal Paper

Title

SYNERGISTIC ACTIVITY OF ECONAZOLE-NITRATE AND CHELERYTHRINE AGAINST CLINICAL ISOLATES OF CANDIDA ALBICANS

Pages

  567-573

Abstract

 The aim of this investigation was to assess the in-vitro interaction of two antifungal agents, ECONAZOLE-NITRATE and CHELERYTHRINE, against ten fluconazole-resistant clinical isolates and one ATCC type strain 10231 of CANDIDA ALBICANS. The checkerboard micro dilution method was performed according to the recommendations of the National Committee for Clinical Laboratory Standards, and the results were determined by visual examination. The interaction intensity was tested in all isolates using the fractional inhibitory concentration index (FICI). These experiments showed SYNERGISM between ECONAZOLE-NITRATE and CHELERYTHRINE in antifungal activity against C. albicans, and no antagonistic activity was observed in any of the strains tested. Moreover, time-kill curves were performed with selected strains to confirm the positive interactions. The similarity between the results of the FICI values and the time-kill curves revealed that CHELERYTHRINE greatly enhances the antifungal effects of ECONAZOLE-NITRATE against isolates of C. albicans. This synergistic effect may markedly reduce the dose of ECONAZOLE-NITRATE required to treat candidiasis, thereby decreasing the ECONAZOLE-NITRATE toxic side effects. This novel SYNERGISM might provide a potential combination treatment against fungal infections.

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    • Cite

    APA: Copy

    CHEN, ZHIBAO, LI, XINRAN, WU, XIUPING, WANG, WEI, WANG, WENDONG, XIN, MINGXUN, SHEN, FENGGE, LIU, LIHUI, LIANG, JUNCHAO, LI, LEI, & YU, LU. (2014). SYNERGISTIC ACTIVITY OF ECONAZOLE-NITRATE AND CHELERYTHRINE AGAINST CLINICAL ISOLATES OF CANDIDA ALBICANS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 567-573. SID. https://sid.ir/paper/288228/en

    Vancouver: Copy

    CHEN ZHIBAO, LI XINRAN, WU XIUPING, WANG WEI, WANG WENDONG, XIN MINGXUN, SHEN FENGGE, LIU LIHUI, LIANG JUNCHAO, LI LEI, YU LU. SYNERGISTIC ACTIVITY OF ECONAZOLE-NITRATE AND CHELERYTHRINE AGAINST CLINICAL ISOLATES OF CANDIDA ALBICANS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):567-573. Available from: https://sid.ir/paper/288228/en

    IEEE: Copy

    ZHIBAO CHEN, XINRAN LI, XIUPING WU, WEI WANG, WENDONG WANG, MINGXUN XIN, FENGGE SHEN, LIHUI LIU, JUNCHAO LIANG, LEI LI, and LU YU, “SYNERGISTIC ACTIVITY OF ECONAZOLE-NITRATE AND CHELERYTHRINE AGAINST CLINICAL ISOLATES OF CANDIDA ALBICANS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 567–573, 2014, [Online]. Available: https://sid.ir/paper/288228/en

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