SYNTHESIS OF SOME NOVEL CHROMENOPYRIMIDINE DERIVATIVES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITIES

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MOBINIKHALEDI AKBAR; FOROUGHIFAR NASER; MOSLEH TAHERE; HAMTA AHMAD

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:3 Page(s): 873-879

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Title

SYNTHESIS OF SOME NOVEL CHROMENOPYRIMIDINE DERIVATIVES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITIES

Author(s)

MOBINIKHALEDI AKBAR | FOROUGHIFAR NASER | MOSLEH TAHERE | HAMTA AHMAD | Issue Writer Certificate

Keywords

IMINE

CHROMENOPYRIMIDINE

PYRANOPYRIMIDINE

ANTIBACTERIAL

MULTICOMPONENT

Abstract

Pyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, ANTIBACTERIAL, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensivity and anti-convulsant agents. As a part of our research work in the synthesis of pyrimidines containing biological activities, a series of CHROMENOPYRIMIDINE derivatives were synthesized by reaction of an intermediate IMINE and ammonia derivatives in good to high yields. All synthesized compounds were characterized using IR and NMR (1H and 13C) spectroscopy and elemental analysis data. The ANTIBACTERIAL activity of these compounds was investigated against Staphylococcus aureus (RTCC, 1885), and Escherichia Coli (ATCC, 35922).

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APA: Copy

MOBINIKHALEDI, AKBAR, FOROUGHIFAR, NASER, MOSLEH, TAHERE, & HAMTA, AHMAD. (2014). SYNTHESIS OF SOME NOVEL CHROMENOPYRIMIDINE DERIVATIVES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(3), 873-879. SID. https://sid.ir/paper/288269/en

Vancouver: Copy

MOBINIKHALEDI AKBAR, FOROUGHIFAR NASER, MOSLEH TAHERE, HAMTA AHMAD. SYNTHESIS OF SOME NOVEL CHROMENOPYRIMIDINE DERIVATIVES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(3):873-879. Available from: https://sid.ir/paper/288269/en

IEEE: Copy

AKBAR MOBINIKHALEDI, NASER FOROUGHIFAR, TAHERE MOSLEH, and AHMAD HAMTA, “SYNTHESIS OF SOME NOVEL CHROMENOPYRIMIDINE DERIVATIVES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 3, pp. 873–879, 2014, [Online]. Available: https://sid.ir/paper/288269/en

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