SYNTHESIS AND BIOLOGICAL INVESTIGATION OF SOME NOVEL SULFONAMIDE AND AMIDE DERIVATIVES CONTAINING COUMARIN MOIETIES

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SAEEDI MINA; GOLI FERESHTEH; MAHDAVI MOHAMMAD; DEHGHAN GHOLAMREZA; FARAMARZI MOHAMMAD ALI; FOROUMADI ALIREZA; SHAFIEE ABBAS

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:3 Page(s): 881-892

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Title

SYNTHESIS AND BIOLOGICAL INVESTIGATION OF SOME NOVEL SULFONAMIDE AND AMIDE DERIVATIVES CONTAINING COUMARIN MOIETIES

Author(s)

Keywords

SULFONAMIDES

AMIDES

COUMARINS

ANTIOXIDANT ACTIVITY

ANTIMICROBIAL

Abstract

New sulfonamide and amide derivatives containing coumarin moieties; oxo-2H-chromen-sulfamoylphenylacetamides and oxo-2H-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of COUMARINS. The structures of compounds were elucidated by IR and NMR spectra and also analytical elemental analysis. In the next step, the above mentioned compounds were screened for their ANTIMICROBIAL and antioxidant activities.Their ANTIMICROBIAL activity was assigned using the conventional agar dilution method and the ANTIOXIDANT ACTIVITY was assessed using two methods, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and ferric reducing antioxidant power (FRAP) assay. Although the compounds showed no remarkable ANTIMICROBIAL activities, most of them exhibited good antioxidant activities. Compounds 5b showed the most potent DPPH activity, whereas 8c wasthe most efficient compound in FRAP assay.

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APA: Copy

SAEEDI, MINA, GOLI, FERESHTEH, MAHDAVI, MOHAMMAD, DEHGHAN, GHOLAMREZA, FARAMARZI, MOHAMMAD ALI, FOROUMADI, ALIREZA, & SHAFIEE, ABBAS. (2014). SYNTHESIS AND BIOLOGICAL INVESTIGATION OF SOME NOVEL SULFONAMIDE AND AMIDE DERIVATIVES CONTAINING COUMARIN MOIETIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(3), 881-892. SID. https://sid.ir/paper/288283/en

Vancouver: Copy

SAEEDI MINA, GOLI FERESHTEH, MAHDAVI MOHAMMAD, DEHGHAN GHOLAMREZA, FARAMARZI MOHAMMAD ALI, FOROUMADI ALIREZA, SHAFIEE ABBAS. SYNTHESIS AND BIOLOGICAL INVESTIGATION OF SOME NOVEL SULFONAMIDE AND AMIDE DERIVATIVES CONTAINING COUMARIN MOIETIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(3):881-892. Available from: https://sid.ir/paper/288283/en

IEEE: Copy

MINA SAEEDI, FERESHTEH GOLI, MOHAMMAD MAHDAVI, GHOLAMREZA DEHGHAN, MOHAMMAD ALI FARAMARZI, ALIREZA FOROUMADI, and ABBAS SHAFIEE, “SYNTHESIS AND BIOLOGICAL INVESTIGATION OF SOME NOVEL SULFONAMIDE AND AMIDE DERIVATIVES CONTAINING COUMARIN MOIETIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 3, pp. 881–892, 2014, [Online]. Available: https://sid.ir/paper/288283/en

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