MCL-1 IS UP REGULATED BY PRENYLATED COUMARIN, UMBELLIPRENIN IN JURKAT CELLS

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GHOLAMI OMID; JEDDI TEHRANI MAHMOOD; IRANSHAHI MEHRDAD; ZARNANI AMIR HASSAN; ZIAI SEYED ALI

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:4 Page(s): 1387-1392

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Information Journal Paper

Title

MCL-1 IS UP REGULATED BY PRENYLATED COUMARIN, UMBELLIPRENIN IN JURKAT CELLS

Author(s)

Keywords

UMBELLPRENIN

JURKAT CELL

APOPTOSIS

MCL-1

REAL TIME PCR

Abstract

Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy in the western world and exists as subtypes with very different clinical courses. Myeloid cell leukemia 1 (Mcl-1) is one member of Bcl-2 family proteins that has been shown to be expressed in various tissues and malignant cells, including CLL, where its expression is significantly associated with a failure to achieve complete remission following cytotoxic therapy.Induction of APOPTOSIS by prenylated coumarin, umbelliprenin, in JURKAT CELLs was previously shown. We examined whether umbelliprenin can down-regulate MCL-1 gene and protein in JURKAT CELLs. In this regard cells were incubated by umbelliprenin, and then down- regulation of MCL-1 gene was studied by REAL TIME PCR method. Moreover, down-regulation of MCL-1 protein was studied by western blot analysis.We showed that, expression of MCL-1 mRNA was increased from 1 hour to 3 hours incubation٫ but this increase has a scale down pattern. Moreover umbelliprenin could inhibit MCL-1 protein. In conclusion umbelliprenin treatment modulates MCL-1 expression at both the transcriptional and posttranslational levels.

Cites

UMBELLIPRENIN IS POTENTIALLY TOXIC AGAINST THE HT29, CT26, MCF-7, 4T1, A172, AND GL26 CELL LINES, POTENTIALLY HARMFUL AGAINST BONE MARROW-DERIVED STEM CELLS, AND NON-TOXIC AGAINST PERIPHERAL BLOOD MONONUCLEAR CELLS

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APA: Copy

GHOLAMI, OMID, JEDDI TEHRANI, MAHMOOD, IRANSHAHI, MEHRDAD, ZARNANI, AMIR HASSAN, & ZIAI, SEYED ALI. (2014). MCL-1 IS UP REGULATED BY PRENYLATED COUMARIN, UMBELLIPRENIN IN JURKAT CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(4), 1387-1392. SID. https://sid.ir/paper/288317/en

Vancouver: Copy

GHOLAMI OMID, JEDDI TEHRANI MAHMOOD, IRANSHAHI MEHRDAD, ZARNANI AMIR HASSAN, ZIAI SEYED ALI. MCL-1 IS UP REGULATED BY PRENYLATED COUMARIN, UMBELLIPRENIN IN JURKAT CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(4):1387-1392. Available from: https://sid.ir/paper/288317/en

IEEE: Copy

OMID GHOLAMI, MAHMOOD JEDDI TEHRANI, MEHRDAD IRANSHAHI, AMIR HASSAN ZARNANI, and SEYED ALI ZIAI, “MCL-1 IS UP REGULATED BY PRENYLATED COUMARIN, UMBELLIPRENIN IN JURKAT CELLS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 4, pp. 1387–1392, 2014, [Online]. Available: https://sid.ir/paper/288317/en

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