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Information Journal Paper

Title

ELEVATED VANCOMYCIN TROUGH CONCENTRATION: INCREASED EFFICACY AND/OR TOXICITY?

Pages

  1241-1247

Abstract

 VANCOMYCIN susceptibility of methicillin-resistant Staphylococcus aureus has been changed over time and its average minimum inhibitory concentration increased from 1.5 to 1.75 mg/L.A recently published guideline by the American Society of Health Pharmacist recommended a daily dose of 15-20 mg/Kg every 8 to 12 hours of VANCOMYCIN to achieve a trough concentration between 15-20 mg/L for treatment of severe infections.Medical records of 69 patients from infectious ward of Imam Khomeini hospital, with suspected or confirmed gram-positive infection who had at least one TROUGH LEVEL of VANCOMYCIN, were evaluated regarding VANCOMYCIN therapeutic goal; EFFICACY and renal safety. Most of patients (60.6%) with severe infections did not achieve the recommended VANCOMYCIN TROUGH LEVEL during treatment course. Time to normalization of the signs and symptoms of infection did not correlate with the patients’ serum VANCOMYCIN TROUGH LEVELs. At the end of treatment course, there was no significant correlation between patients’ creatinine clearance and VANCOMYCIN TROUGH LEVELs (P=0.32). However, patients’cratinine clearance showed a negatively significant correlation with TROUGH LEVEL of VANCOMYCIN (P=0.01). VANCOMYCIN induced nephrotoxicity was detected in 4.3% of the patients. These data showed that VANCOMYCIN TROUGH LEVEL may not necessarily assure treatment success, and also it would not essentially predict the risk of VANCOMYCIN induced nephrotoxicity. However, more well designed studies with larger sample size needed for better clinical and practical judgment.

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    APA: Copy

    ELYASI, SEPIDEH, KHALILI, HOSSEIN, DASHTI KHAVIDAKI, SIMIN, EMADI KOOCHAK, HAMID, MOHAMMADPOUR, AMIRHOOSHANG, & ABDOLLAHI, ALIREZA. (2014). ELEVATED VANCOMYCIN TROUGH CONCENTRATION: INCREASED EFFICACY AND/OR TOXICITY?. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(4), 1241-1247. SID. https://sid.ir/paper/288323/en

    Vancouver: Copy

    ELYASI SEPIDEH, KHALILI HOSSEIN, DASHTI KHAVIDAKI SIMIN, EMADI KOOCHAK HAMID, MOHAMMADPOUR AMIRHOOSHANG, ABDOLLAHI ALIREZA. ELEVATED VANCOMYCIN TROUGH CONCENTRATION: INCREASED EFFICACY AND/OR TOXICITY?. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(4):1241-1247. Available from: https://sid.ir/paper/288323/en

    IEEE: Copy

    SEPIDEH ELYASI, HOSSEIN KHALILI, SIMIN DASHTI KHAVIDAKI, HAMID EMADI KOOCHAK, AMIRHOOSHANG MOHAMMADPOUR, and ALIREZA ABDOLLAHI, “ELEVATED VANCOMYCIN TROUGH CONCENTRATION: INCREASED EFFICACY AND/OR TOXICITY?,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 4, pp. 1241–1247, 2014, [Online]. Available: https://sid.ir/paper/288323/en

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