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Information Journal Paper

Title

BERBERINE CHLORIDE PRETREATMENT EXHIBITS NEUROPROTECTIVE EFFECT AGAINST 6-HYDROXYDOPAMINE-INDUCED NEURONAL INSULT IN RAT

Pages

  1145-1152

Abstract

 Parkinson’s disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid BERBERINE (BBR), this study was conducted to assess whether BBR pretreatment could attenuate behavioral and neuronal derangement in 6-HYDROXYDOPAMINE (6-OHDA)-induced model of PD in the rat. Unilateral intrastriatal 6-OHDA-lesioned rats received BBR at doses of 25 and/or 50 mg/kg (i.p.) three times at an interval of 24 h, started 2 days before the surgery. After 1 week, apo morphine caused significant contralateral rotations and a significant reduction in the number of Nisslstained and tyrosine-hydroxylase (TH)-positive neurons on the left side of the substantianigra. BBR pretreatment at a dose of 50 mg/kg significantly reduced rotations and prevented loss of TH-positive neurons. These results indicate pre-lesion administration of BBR could protect against 6-OHDA toxicity and this may be of benefit besides other available therapies in PD.

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    APA: Copy

    NEGAHDAR, FERAIDOON, MEHDIZADEH, MEHDI, JOGHATAEI, MOHAMMAD TAGHI, ROGHANI, MEHRDAD, MEHRAEEN, FERESHTEH, & POORGHAYOOMI, EHSAN. (2015). BERBERINE CHLORIDE PRETREATMENT EXHIBITS NEUROPROTECTIVE EFFECT AGAINST 6-HYDROXYDOPAMINE-INDUCED NEURONAL INSULT IN RAT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(4), 1145-1152. SID. https://sid.ir/paper/288391/en

    Vancouver: Copy

    NEGAHDAR FERAIDOON, MEHDIZADEH MEHDI, JOGHATAEI MOHAMMAD TAGHI, ROGHANI MEHRDAD, MEHRAEEN FERESHTEH, POORGHAYOOMI EHSAN. BERBERINE CHLORIDE PRETREATMENT EXHIBITS NEUROPROTECTIVE EFFECT AGAINST 6-HYDROXYDOPAMINE-INDUCED NEURONAL INSULT IN RAT. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(4):1145-1152. Available from: https://sid.ir/paper/288391/en

    IEEE: Copy

    FERAIDOON NEGAHDAR, MEHDI MEHDIZADEH, MOHAMMAD TAGHI JOGHATAEI, MEHRDAD ROGHANI, FERESHTEH MEHRAEEN, and EHSAN POORGHAYOOMI, “BERBERINE CHLORIDE PRETREATMENT EXHIBITS NEUROPROTECTIVE EFFECT AGAINST 6-HYDROXYDOPAMINE-INDUCED NEURONAL INSULT IN RAT,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 4, pp. 1145–1152, 2015, [Online]. Available: https://sid.ir/paper/288391/en

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