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Information Journal Paper

Title

PREPARATION AND CHARACTERIZATION OF STABLE NANOLIPOSOMAL FORMULATION OF FLUOXETINE AS A POTENTIAL ADJUVANT THERAPY FOR DRUG-RESISTANT TUMORS

Pages

  3-14

Abstract

 Chemotherapy research highly prioritizes overcoming the multidrug resistance (MDR) in human tumors. Liposomal formulation of FLUOXETINE, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and STABILITY. Liposomes were prepared using different active loading techniques. The influence of different formulation variables such as loading methodology, type of main lipid, addition of PEGylated lipid and cholesterol percentage was evaluated to achieve required entrapment efficiency, in vitro release behavior and STABILITY. The studied parameters had significant effect on physicochemical characteristics of the nanocarriers. High FLUOXETINE encapsulation efficiency (83%±3%) and appropriate particle size (101±12 nm) and zeta potential (-9±2 mv) were achieved for PEGYLATION liposomes composed of DSPE-PEG, DSPC and cholesterol at respective molar ratio of 5: 70: 25. An in vitro FLUOXETINE release of about 20% in 48 h was observed from optimum formulation. Atomic force microscopy (AFM) studies confirmed homogeneous distribution of particles and spherical shape with smooth surface. The optimum formulation was stable for 9 days when incubated at 37 oC. The results of this study are very encouraging for application of the developed FLUOXETINE liposomal formulation in drug-resistant tumor models.

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    APA: Copy

    HAERI, AZADEH, ALINAGHIAN, BEHDOKHT, DAEIHAMED, MARJAN, & DADASHZADEH, SIMIN. (2014). PREPARATION AND CHARACTERIZATION OF STABLE NANOLIPOSOMAL FORMULATION OF FLUOXETINE AS A POTENTIAL ADJUVANT THERAPY FOR DRUG-RESISTANT TUMORS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(SUPPL), 3-14. SID. https://sid.ir/paper/288418/en

    Vancouver: Copy

    HAERI AZADEH, ALINAGHIAN BEHDOKHT, DAEIHAMED MARJAN, DADASHZADEH SIMIN. PREPARATION AND CHARACTERIZATION OF STABLE NANOLIPOSOMAL FORMULATION OF FLUOXETINE AS A POTENTIAL ADJUVANT THERAPY FOR DRUG-RESISTANT TUMORS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(SUPPL):3-14. Available from: https://sid.ir/paper/288418/en

    IEEE: Copy

    AZADEH HAERI, BEHDOKHT ALINAGHIAN, MARJAN DAEIHAMED, and SIMIN DADASHZADEH, “PREPARATION AND CHARACTERIZATION OF STABLE NANOLIPOSOMAL FORMULATION OF FLUOXETINE AS A POTENTIAL ADJUVANT THERAPY FOR DRUG-RESISTANT TUMORS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. SUPPL, pp. 3–14, 2014, [Online]. Available: https://sid.ir/paper/288418/en

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