SYNTHESIS OF N-ARYLMETHYL SUBSTITUTED INDOLE DERIVATIVES AS NEW ANTIPLATELET AGGREGATION AGENTS

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FAGHIH AKHLAGHI MASOUD; AMIDI SALIMEH; ESFAHANIZADEH MARJAN; DAEIHAMED MARJAN; KOBARFARD FARZAD

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:SUPPL Page(s): 35-42

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Title

SYNTHESIS OF N-ARYLMETHYL SUBSTITUTED INDOLE DERIVATIVES AS NEW ANTIPLATELET AGGREGATION AGENTS

Author(s)

Keywords

1-(SUBSTITUTED BENZYL)-3-(PHENYLIMINO)INDOLIN-2-ONE

ANTIPLATELET

PLATELET AGGREGATION

N-ARYLMETHYL INDOLE

Abstract

A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced PLATELET AGGREGATION in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then activated using sodium hydride and reacted with the proper substituted benzyl halides. Among the tested compounds, derivatives 4a, 4c, 4d, 4f-i and 4k were the most potent compounds with satisfactory IC50 values (under 38.5 mM) for inhibition of PLATELET AGGREGATION induced by arachidonic acid.All indole derivatives without substitution on position 1 of the indole ring, exhibited either weaker activities or were not active at all.

Cites

SYNTHESIS, ANTIPLATELET ACTIVITY AND CYTOTOXICITY ASSESSMENT OF INDOLE-BASED HYDRAZONE DERIVATIVES

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APA: Copy

FAGHIH AKHLAGHI, MASOUD, AMIDI, SALIMEH, ESFAHANIZADEH, MARJAN, DAEIHAMED, MARJAN, & KOBARFARD, FARZAD. (2014). SYNTHESIS OF N-ARYLMETHYL SUBSTITUTED INDOLE DERIVATIVES AS NEW ANTIPLATELET AGGREGATION AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(SUPPL), 35-42. SID. https://sid.ir/paper/288436/en

Vancouver: Copy

FAGHIH AKHLAGHI MASOUD, AMIDI SALIMEH, ESFAHANIZADEH MARJAN, DAEIHAMED MARJAN, KOBARFARD FARZAD. SYNTHESIS OF N-ARYLMETHYL SUBSTITUTED INDOLE DERIVATIVES AS NEW ANTIPLATELET AGGREGATION AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(SUPPL):35-42. Available from: https://sid.ir/paper/288436/en

IEEE: Copy

MASOUD FAGHIH AKHLAGHI, SALIMEH AMIDI, MARJAN ESFAHANIZADEH, MARJAN DAEIHAMED, and FARZAD KOBARFARD, “SYNTHESIS OF N-ARYLMETHYL SUBSTITUTED INDOLE DERIVATIVES AS NEW ANTIPLATELET AGGREGATION AGENTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. SUPPL, pp. 35–42, 2014, [Online]. Available: https://sid.ir/paper/288436/en

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