مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SYNTHESIS, ANTIPLATELET ACTIVITY AND CYTOTOXICITY ASSESSMENT OF INDOLE-BASED HYDRAZONE DERIVATIVES

Pages

  1077-1086

Abstract

 A series of INDOLE-based aryl (aroyl) hydrazone analogs of antiplatelet INDOLE-3- carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, ARACHIDONIC ACID and COLLAGEN were used as inducers of platelet aggregation. Based on the results, substituted phenylhydrazones showed promising activity. Among them, compound 1i was the most potent derivative with an IC50 comparable to that of indomethacin as a standard drug. The hydrazine derivatives were also tested for their cytotoxicity using on platelet concentrates and fibroblast L929 cells. The majority of the derivatives showed an acceptable selectivity towards ANTIPLATELET AGGREGATION activity.Based on the activity data, phenylhydrazone derivatives (1a-i) exhibited considerable antiplatelet activity and minimal toxic effect on platelet cells. The results of the present study could provide a better understanding of the structure activity relationship of antiplatelet INDOLEhydrazones.

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    Cite

    APA: Copy

    TEHRANI KAMALEDDIN, HAJ MOHAMMAD EBRAHIM, ESFAHANIZADEH, MARJAN, MASHAYEKHI, VIDA, HASHEMI, MARYAM, KOBARFARD, FARZAD, GHAREBAGHI, FARHAD, & MOHEBBI, SHOHREH. (2015). SYNTHESIS, ANTIPLATELET ACTIVITY AND CYTOTOXICITY ASSESSMENT OF INDOLE-BASED HYDRAZONE DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(4), 1077-1086. SID. https://sid.ir/paper/288404/en

    Vancouver: Copy

    TEHRANI KAMALEDDIN HAJ MOHAMMAD EBRAHIM, ESFAHANIZADEH MARJAN, MASHAYEKHI VIDA, HASHEMI MARYAM, KOBARFARD FARZAD, GHAREBAGHI FARHAD, MOHEBBI SHOHREH. SYNTHESIS, ANTIPLATELET ACTIVITY AND CYTOTOXICITY ASSESSMENT OF INDOLE-BASED HYDRAZONE DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(4):1077-1086. Available from: https://sid.ir/paper/288404/en

    IEEE: Copy

    HAJ MOHAMMAD EBRAHIM TEHRANI KAMALEDDIN, MARJAN ESFAHANIZADEH, VIDA MASHAYEKHI, MARYAM HASHEMI, FARZAD KOBARFARD, FARHAD GHAREBAGHI, and SHOHREH MOHEBBI, “SYNTHESIS, ANTIPLATELET ACTIVITY AND CYTOTOXICITY ASSESSMENT OF INDOLE-BASED HYDRAZONE DERIVATIVES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 4, pp. 1077–1086, 2015, [Online]. Available: https://sid.ir/paper/288404/en

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