UV SPECTROPHOTOMETRIC DETERMINATION AND VALIDATION OF HYDROQUINONE IN LIPOSOME

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KHOSHNEVISZADEH R.; FAZLY BAZZAZ BIBI SEDIGHEH; HOUSAINDOKHT MOHAMMAD REZA; EBRAHIM HABIBI AZADEH; RAJABI OMID

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:2 Page(s): 473-478

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Title

UV SPECTROPHOTOMETRIC DETERMINATION AND VALIDATION OF HYDROQUINONE IN LIPOSOME

Author(s)

Keywords

Hydroquinone

Liposome

UV spectroscopy

Validation

Abstract

The method has been developed and validated for the determination of Hydroquinone in liposomal formulation. The samples were dissolved in methanol and evaluated in 293 nm. The Validation parameters such as linearity, accuracy, precision, specificity, limit of detection (LOD) and limit of quantitation (LOQ) were determined. The calibration curve was linear in 1-50 μ g/mL range of Hydroquinone analyte with a regression coefficient of 0. 9998. This study showed that the liposomal Hydroquinone composed of phospholipid (7. 8 %), cholesterol (1. 5 %), alpha ketopherol (0. 17 %) and Hydroquinone (0. 5 %) did not absorb wavelength of 293 nm if it diluted 500 times by methanol. The concentration of Hydroquinone reached 10 μ g/mL after 500 times of dilution. Furthermore, various Validation parameters as per ICH Q2B guideline were tested and found accordingly. The recovery percentages of liposomal Hydroquinone were found 102 ± 0. 8, 99 ± 0. 2 and 98 ± 0. 4 for 80%, 100% and 120% respectively. The relative standard deviation values of inter and intra-day precisions were <%2. LOD and LOQ were 0. 24 and 0. 72 μ g/mL respectively.

Cites

A COMPARISON OF EXPLANATION METHODS OF ENCAPSULATION EFFICACY OF HYDROQUINONE IN A LIPOSOMAL SYSTEM

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APA: Copy

KHOSHNEVISZADEH, R., FAZLY BAZZAZ, BIBI SEDIGHEH, HOUSAINDOKHT, MOHAMMAD REZA, EBRAHIM HABIBI, AZADEH, & RAJABI, OMID. (2015). UV SPECTROPHOTOMETRIC DETERMINATION AND VALIDATION OF HYDROQUINONE IN LIPOSOME. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 473-478. SID. https://sid.ir/paper/288439/en

Vancouver: Copy

KHOSHNEVISZADEH R., FAZLY BAZZAZ BIBI SEDIGHEH, HOUSAINDOKHT MOHAMMAD REZA, EBRAHIM HABIBI AZADEH, RAJABI OMID. UV SPECTROPHOTOMETRIC DETERMINATION AND VALIDATION OF HYDROQUINONE IN LIPOSOME. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):473-478. Available from: https://sid.ir/paper/288439/en

IEEE: Copy

R. KHOSHNEVISZADEH, BIBI SEDIGHEH FAZLY BAZZAZ, MOHAMMAD REZA HOUSAINDOKHT, AZADEH EBRAHIM HABIBI, and OMID RAJABI, “UV SPECTROPHOTOMETRIC DETERMINATION AND VALIDATION OF HYDROQUINONE IN LIPOSOME,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 473–478, 2015, [Online]. Available: https://sid.ir/paper/288439/en

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