Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine Derivatives

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ESFAHANIZADEH MARJAN; MOHEBBI SHOHREH; Dasht Bozorg Behnam; AMIDI SALIMEH; GUDARZI ALI; AYATOLLAHI SEYED ABDOLMAJID; KOBARFARD FARZAD

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:2 Page(s): 417-424

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Title

Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine Derivatives

Author(s)

Keywords

aminopyrimidines;2

Substituted

diaminopyrimidines;Antiplatelet aggregation

Abstract

A series of novel 2-aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, Ib, IB and II16 exhibited the highest antiplatelet aggregation activity (36. 75, 72. 4, 62. 5 and 80 μ M). None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid. 2-aminopyrimidines were more active than 4, 6-diaminopyrimidines in this respect.

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APA: Copy

ESFAHANIZADEH, MARJAN, MOHEBBI, SHOHREH, Dasht Bozorg, Behnam, AMIDI, SALIMEH, GUDARZI, ALI, AYATOLLAHI, SEYED ABDOLMAJID, & KOBARFARD, FARZAD. (2015). Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine Derivatives. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 417-424. SID. https://sid.ir/paper/288471/en

Vancouver: Copy

ESFAHANIZADEH MARJAN, MOHEBBI SHOHREH, Dasht Bozorg Behnam, AMIDI SALIMEH, GUDARZI ALI, AYATOLLAHI SEYED ABDOLMAJID, KOBARFARD FARZAD. Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine Derivatives. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):417-424. Available from: https://sid.ir/paper/288471/en

IEEE: Copy

MARJAN ESFAHANIZADEH, SHOHREH MOHEBBI, Behnam Dasht Bozorg, SALIMEH AMIDI, ALI GUDARZI, SEYED ABDOLMAJID AYATOLLAHI, and FARZAD KOBARFARD, “Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine Derivatives,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 417–424, 2015, [Online]. Available: https://sid.ir/paper/288471/en

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