Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1, 2, 4-Triazol-3-thiols and their S-substituted Derivatives

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KALHOR MEHDI; Shabani Mahboobeh; NIKOKAR IRAJ; Banisaeed Seyedeh Reyhaneh

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:1 Page(s): 67-75

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Title

Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1, 2, 4-Triazol-3-thiols and their S-substituted Derivatives

Author(s)

KALHOR MEHDI | Shabani Mahboobeh | NIKOKAR IRAJ | Banisaeed Seyedeh Reyhaneh | Issue Writer Certificate

Keywords

Thiosemicarbazide;1

Triazole

thiol;S

alkylation;Microorganisms;Antibacterial activity

Abstract

The thiosemicarbazides 3a-c were appeared by reaction of the corresponding substituted hydrazides 1a-c with allylisothiocyanate 2. Synthesis of some novel 1, 2, 4-Triazole-thiols 4a-c bearing a pyridyl unit using 1-(x-picolinoyl)-4-allyl-thiosemicarbazides (x = 2, 3, 4) in an alkaline solution, is reported. Also, the S-alkylation of Triazole derivatives 5-7a-c is described. The structure of the synthesized compounds resulted from the IR, 1H and-13C NMR spectroscopy and elemental analysis data. The antibacterial studies to all of the synthesized compounds against B. cereus, E. coli, P. aeroginosa, S. aureus and E. faecalis as MIC values are reported. Some of these compounds such as 7a, 4a and 3a exhibited a good to significant antibacterial activity.

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APA: Copy

KALHOR, MEHDI, Shabani, Mahboobeh, NIKOKAR, IRAJ, & Banisaeed, Seyedeh Reyhaneh. (2015). Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1, 2, 4-Triazol-3-thiols and their S-substituted Derivatives. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(1), 67-75. SID. https://sid.ir/paper/288506/en

Vancouver: Copy

KALHOR MEHDI, Shabani Mahboobeh, NIKOKAR IRAJ, Banisaeed Seyedeh Reyhaneh. Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1, 2, 4-Triazol-3-thiols and their S-substituted Derivatives. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(1):67-75. Available from: https://sid.ir/paper/288506/en

IEEE: Copy

MEHDI KALHOR, Mahboobeh Shabani, IRAJ NIKOKAR, and Seyedeh Reyhaneh Banisaeed, “Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1, 2, 4-Triazol-3-thiols and their S-substituted Derivatives,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 1, pp. 67–75, 2015, [Online]. Available: https://sid.ir/paper/288506/en

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