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Information Journal Paper

Title

Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells In-vitro

Pages

  251-261

Abstract

 The objective of this study was to observe the apoptosis-inducing effect and mechanism of Baicalin on human cervical cancer HeLa cells. The inhibitory effect of Baicalin on the growth of HeLa cells was measured by MTT assay, and cell proliferation and migration was analyzed by cell scratch assay. Morphological changes of apoptotic cells were viewed by the light microscope and electron microscope, and cell growth arrest was confirmed by flow cytometry. Moreover, Western blot was used for investigating the expression of apoptosis related proteins; spectrophotometry was used to examine Caspase-3 activation. Our results showed that Baicalin could inhibit the proliferation of HeLa cells via induction of apoptosis in a time and dosedependent manner (P<0. 01). Apoptotic signaling induced by Baicalin was characterized by up-regulating Bax, Fas, FasL and Caspase-8 protein expression, and down-regulating of Bcl-2 protein expression. These results indicated that Baicalin-induced apoptosis involved activation Caspase-3 in HeLa cells through the intracellular Mitochondrial pathway and the surface Death receptor pathway.

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    APA: Copy

    Peng, Yong, Fu, Zhan zhao, Guo, Cong Shan, ZHANG, YAN XIA, Di, Ya, Jiang, Bin, & Li, Qing Wang. (2015). Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells In-vitro. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(1), 251-261. SID. https://sid.ir/paper/288521/en

    Vancouver: Copy

    Peng Yong, Fu Zhan zhao, Guo Cong Shan, ZHANG YAN XIA, Di Ya, Jiang Bin, Li Qing Wang. Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells In-vitro. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(1):251-261. Available from: https://sid.ir/paper/288521/en

    IEEE: Copy

    Yong Peng, Zhan zhao Fu, Cong Shan Guo, YAN XIA ZHANG, Ya Di, Bin Jiang, and Qing Wang Li, “Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells In-vitro,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 1, pp. 251–261, 2015, [Online]. Available: https://sid.ir/paper/288521/en

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