Immunomodulatory Effects of Bee Venom in Human Synovial Fibroblast Cell Line

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MOHAMMADI EBRAHIM; VATANPOUR HOSSEIN; SHIRAZI FARSHAD H.

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:1 Page(s): 313-320

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Title

Immunomodulatory Effects of Bee Venom in Human Synovial Fibroblast Cell Line

Author(s)

MOHAMMADI EBRAHIM | VATANPOUR HOSSEIN | SHIRAZI FARSHAD H. | Issue Writer Certificate

Keywords

Bee venom

Cigarette

Cytokine

Sirt1

Fibroblast-like synoviocytes

Abstract

As in Iranian traditional medicine, Bee venom (BV) is a promising treatment for the rheumatoid arthritis (RA) which is considered as a problematic human chronic inflammatory disease in the present time. Smoking is considered to be a major risk factor in RA onset and severity. The main aim of this study is to investigate the effects of BV on Cigarette smokeinduced inflammatory response in Fibroblast-like synoviocytes (FLS). Cytotoxicity of Cigarette smoke condensate (CSC) and Bee venom were determined by the tetrazolium (MTT) method in cultured synovial fibroblastes. The expression of interleukin-1β and sirtuin1 mRNA were analyzed by SYBR green real-time quantitative PCR. Differences between the mean values of treated and untreated groups were assessed by student t-test. Based on MTT assay, CSC and BV did not exert any significant cytotoxic effects up to 40 μ g/mL and 10 μ g/mL, respectively. Our results showed that interleukin-1β mRNA level was significantly up-regulated by CSC treatments in LPS-stimulated synoviocytes in a dose-dependent manner. Conversely, the expressions of IL-1β and Sirt1 were up-regulated even in lower concentrations of BV and attenuated at higher concentrations. Also, BV attenuated the CSC-induced and LPS-induced inflammatory responses in synovial fibroblasts. Our results support the epidemiological studies indicating pro-inflammatory effects of CSC and anti-inflammatory effects of BV on FLS cell line.

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APA: Copy

MOHAMMADI, EBRAHIM, VATANPOUR, HOSSEIN, & SHIRAZI, FARSHAD H.. (2015). Immunomodulatory Effects of Bee Venom in Human Synovial Fibroblast Cell Line. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(1), 313-320. SID. https://sid.ir/paper/288522/en

Vancouver: Copy

MOHAMMADI EBRAHIM, VATANPOUR HOSSEIN, SHIRAZI FARSHAD H.. Immunomodulatory Effects of Bee Venom in Human Synovial Fibroblast Cell Line. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(1):313-320. Available from: https://sid.ir/paper/288522/en

IEEE: Copy

EBRAHIM MOHAMMADI, HOSSEIN VATANPOUR, and FARSHAD H. SHIRAZI, “Immunomodulatory Effects of Bee Venom in Human Synovial Fibroblast Cell Line,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 1, pp. 313–320, 2015, [Online]. Available: https://sid.ir/paper/288522/en

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