Formulation and Evaluation of Nanocrystals of a Lipid Lowering Agent

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Louis Dina

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:1 Page(s): 71-82

Download Full-Text

View:

183

Download:

119

Cites:

Information Journal Paper

Title

Formulation and Evaluation of Nanocrystals of a Lipid Lowering Agent

Author(s)

Louis Dina | Issue Writer Certificate

Keywords

Atorvastatin

Bioavailability

Hhomogenization

Nanocrystals

Stabilizer

Abstract

Atorvastatin calcium, the lipid lowering agent, is taken as a model drug characterized by poor water solubility and Bioavailability. In this study an attempt was made for preparation of Nanocrystals using high pressure homogenization. A number of Stabilizers were included as well as polymers at different concentrations, and the formulations were homogenized for ten cycles at a pressure of 1000 bars. The obtained nano crystals were evaluated by determining their size, zeta potential, saturated solubility and dissolution rate. Results revealed that Formulation 3, containing (10: 1) drug to sodium lauryl sulphate ratio, possessed the highest saturated solubility and dissolution rate, and hence was analyzed by X-ray diffraction analysis, differential scanning calorimetry, Fourrier transform infrared spectroscopy and scanning electron microscopy. An in-vivo study was carried out on the successful formulation in comparison to drug powder using rats as experimental animals. A significant increase in the area under the concentration-time curve Cpmax and MRT for Nanocrystals was observed in comparison to the untreated Atorvastatin calcium.

Cites

No record.

References

No record.

Cite

APA: Copy

Louis, Dina. (2016). Formulation and Evaluation of Nanocrystals of a Lipid Lowering Agent. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 71-82. SID. https://sid.ir/paper/288526/en

Vancouver: Copy

Louis Dina. Formulation and Evaluation of Nanocrystals of a Lipid Lowering Agent. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):71-82. Available from: https://sid.ir/paper/288526/en

IEEE: Copy

Dina Louis, “Formulation and Evaluation of Nanocrystals of a Lipid Lowering Agent,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 71–82, 2016, [Online]. Available: https://sid.ir/paper/288526/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops